ネリドロン酸
ネリドロン酸 物理性質
- 融点 :
- 245°
- 沸点 :
- 600.1±65.0 °C(Predicted)
- 比重(密度) :
- 1.658±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- H2O: 8 mg/mL、可溶
- 外見 :
- 個体
- 酸解離定数(Pka):
- 1.93±0.10(Predicted)
- 色:
- 白い
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
主な危険性 |
Xn |
|
|
Rフレーズ |
22 |
|
|
WGK Germany |
3 |
|
|
絵表示(GHS) |
|
注意喚起語 |
警告 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
|
注意書き |
P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
P305+P351+P338 |
眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
Sigma-Aldrich Japan
|
N6037 |
≥97% (NMR), solid
Neridronate ≥97% (NMR), solid |
79778-41-9 |
10mg |
¥18400 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
N6037 |
≥97% (NMR), solid
Neridronate ≥97% (NMR), solid |
79778-41-9 |
100mg |
¥99700 |
2024-03-01 |
購入 |
ネリドロン酸 化学特性,用途語,生産方法
説明
Neridronic acid was launched in Italy as intravenous or intramuscular injection for the
treatment of osteogenesis imperfecta. It is the first drug launched worldwide for this
“orphan disease” characterized by a fragility of the bone. Sufferers risk frequent fractures
commencing during infancy, eventually leading to bone deformation and a severe
deterioration of the quality of life and life expectancy. Neridronic acid is structurally related
to the second generation of bisphosphonates characterized by an amino terminal group
and can be synthesized by treating E-aminocaproic acid with phosphoric acid and
phosphorous trichloride. Bisphosphonates, synthetic analogs of the endogenous mineral
deposition inhibitor pyrophosphate, are extremely potent inhibitors of bone resorption and
increase bone mineral density, possibly by inhibiting the activity of osteoclasts and
promoting the death of these bone-eroding cells. In vitro, neridronic acid was a poor
inhibitor of phagocytosis, but significantly and dose dependently inhibited 8glucuronidase
release and superoxide anion production in the rat peritoneal macrophage, two parameters
that may have a part in bone resorption. In a clinical study on patients with osteogenesis
imperfecta, neridronic acid increased remarkably bone mass in young growing individuals.
In adults the changes were less important but still significant.
ネリドロン酸 上流と下流の製品情報
原材料
準備製品
ネリドロン酸 生産企業
Global( 60)Suppliers
79778-41-9(ネリドロン酸)キーワード:
- 79778-41-9
- NERIXIA
- NERIDRONATE
- NERIDRONATE SODIUM HYDRATE
- NERIDRONIC ACID
- 6-AMINO-1-HYDROXYHEXYLIDENE BISPHOSPHONIC ACID
- 6-amino-1-hydroxyhexane-1,1-diphosphonate
- Neridronic
- 6-Amino-1-hydroxyhexylidene bisphosphonic acid, Neridronic acid, Nerixia
- (6-AMino-1-hydroxyhexane-1,1-diyl)diphosphonic acid
- Phosphonic acid,P,P'-(6-aMino-1-hydroxyhexylidene)bis-
- Neridronate
DISCONTINUED, offer N390025
- Neridronate >=97% (NMR), solid
- 6-amino-1-hydroxyhexane-1,1-diphosphonic acid
- (6-Amino-1-hydroxyhexane-1,1-diyl)bis(phosphonic acid)
- ネリドロン酸