安息香酸ナトリウム 化学特性,用途語,生産方法
外観
白色の結晶性の粉末又は粒
定義
本品は、安息香酸(*)のナトリウム塩であり、次の化学式で表される。
参照表示名称：安息香酸
溶解性
無色澄明 (1.0g, 水5mL)
用途
清涼飲料、しょう油
化粧品の成分用途
防腐剤、腐蝕防止剤、香料
効能
高アンモニア血症治療薬, 防腐剤
主な用途／役割
有機系結晶核剤、カルボン酸金属塩タイプ、ＰＰ用
商品名
安息香酸ナトリウム (丸石製薬); 安息香酸ナトリウム (小堺製薬)
説明
Sodium benzoate has the chemical formula NaC
7H
5O
2; it is a widely used food preservative, with E number E211. It is the sodium salt of benzoic acid and exists in this form when dissolved in water. It can be produced by reacting sodium hydroxide with benzoic acid.
化学的特性
Sodium benzoate is a white crystalline solid. It is odorless and nonflammable
天然物の起源
Benzoic acid occurs naturally in many plants and in animals. The salt is not found to occur naturally.
使用
sodium benzoate is a non-toxic, organic salt preservative that is particularly effective against yeast, with some activity against molds and bacteria. It is generally used in concentrations of 0.1 to 0.2 percent.
製造方法
Produced by the neutralization of benzoic acid with sodium bicarbonate, sodium carbonate or sodium hydroxide.
調製方法
Sodium benzoate is prepared by adding benzoic acid to a hot concentrated solution of sodium carbonate until effervescence ceases. The solution is then evaporated, cooled and allowed to crystallize or evaporate to dryness, and then granulated.
定義
sodium benzoate: An either colourlesscrystalline or white amorphouspowder, C
6H
5COONa, soluble inwater and slightly soluble in ethanol.It is made by the reaction of sodiumhydroxide with benzoic acid and isused in the dyestuffs industry and asa food preservative. It was formerlyused as an antiseptic.
一般的な説明
Sodium benzoate is a sodium salt of benzoic acid, that is freely soluble in water compared to benzoic acid. It is generally used as an antimicrobial preservative in cosmetics, food, and pharmaceuticals.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
危険性
Use in foods limited to 0.1%.
応用例（製薬）
Sodium benzoate is used primarily as an antimicrobial preservative
in cosmetics, foods, and pharmaceuticals. It is used in concentrations
of 0.02–0.5% in oral medicines, 0.5% in parenteral products,
and 0.1–0.5% in cosmetics. The usefulness of sodium benzoate as a
preservative is limited by its effectiveness over a narrow pH range.
Sodium benzoate is used in preference to benzoic acid in some
circumstances, owing to its greater solubility. However, in some
applications it may impart an unpleasant flavor to a product.
Sodium benzoate has also been used as a tablet lubricant at 2–5%
w/w concentrations. Solutions of sodium benzoate have also been administered, orally or intravenously, in order to determine liver
function.
安全性プロファイル
Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion, intramuscular, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Larger doses of 8-10 g by mouth may cause nausea and vomiting. Small doses have little or no effect. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Na2O. See also BENZOIC ACID.
安全性
In combination with ascorbic acid (vitamin C, E300), sodium benzoate and potassium benzoate form benzene, a known carcinogen. However, in most beverages that contain both, the benzene levels are below those considered dangerous for consumption. Heat, light and shelf life can affect the rate at which benzene is formed.
職業ばく露
Sodium benzoate is used as a food and feed additive, flavor, packaging material; pharmaceutical; preservative for food products and tobacco; anti-fungal agent; antiseptic, rust, and mildew inhibitor; intermediate in the manufacture of dyes. Used as a human hygiene biocidal product.
貯蔵
Aqueous solutions may be sterilized by autoclaving or filtration. The bulk material should be stored in a well-closed container, in
a cool, dry place.
輸送方法
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
純化方法
Crystallise it from EtOH (12mL/g). [Beilstein 9 IV 27.]
不和合性
Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
規制状況(Regulatory Status)
GRAS listed. Accepted as a food additive in Europe. Included in the
FDA Inactive Ingredients Database (dental preparations; IM and IV
injections; oral capsules, solutions and tablets; rectal; and topical
preparations). Included in nonparenteral medicines licensed in the
UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients.
安息香酸ナトリウム 上流と下流の製品情報
原材料
準備製品