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BIBU 1361二塩酸塩

BIBU 1361二塩酸塩 化学構造式
793726-84-8
CAS番号.
793726-84-8
化学名:
BIBU 1361二塩酸塩
别名:
BIBU 1361二塩酸塩
英語名:
BIBU 1361 DIHYDROCHLORIDE
英語别名:
BIBU 1361;BIBU1361 (BIBU 1361 );BIBU 1361 DIHYDROCHLORIDE;N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]pyrimido[5,4-d]pyrimidin-4-amine;Pyrimido[5,4-d]pyrimidin-4-amine, N-(3-chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-;N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-aminedihydrochloride;N-(3-CHLORO-4-FLUOROPHENYL)-6-[4-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]-PYRIMIDO[5,4-D]PYRIMIDIN-4-AMINE DIHYDROCHLORIDE
CBNumber:
CB0840882
化学式:
C22H27ClFN7
分子量:
443.95
MOL File:
793726-84-8.mol

BIBU 1361二塩酸塩 物理性質

沸点 :
580.0±60.0 °C(Predicted)
比重(密度) :
1.285±0.06 g/cm3(Predicted)
貯蔵温度 :
Desiccate at +4°C
溶解性:
DMSO（微量）、メタノール（微量）
外見 :
個体
酸解離定数(Pka):
10.32±0.25(Predicted)
色:
黄色

安全性情報

BIBU 1361二塩酸塩 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC2417 BIBU 1361二塩酸塩
BIBU 1361 dihydrochloride 		793726-84-8 1mg ￥27000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TOC2417 BIBU 1361二塩酸塩
BIBU 1361 dihydrochloride 		793726-84-8 10mg ￥63000 2018-12-26 購入

BIBU 1361二塩酸塩 化学特性,用途語,生産方法

生物活性

Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC 50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC 50 > 10 μ M). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.

BIBU 1361二塩酸塩 上流と下流の製品情報

原材料

準備製品

BIBU 1361二塩酸塩 生産企業

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793726-84-8(BIBU 1361二塩酸塩)キーワード:

BIBU 1361二塩酸塩
  • 793726-84-8
  • N-(3-CHLORO-4-FLUOROPHENYL)-6-[4-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]-PYRIMIDO[5,4-D]PYRIMIDIN-4-AMINE DIHYDROCHLORIDE
  • BIBU 1361 DIHYDROCHLORIDE
  • N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-aminedihydrochloride
  • N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]pyrimido[5,4-d]pyrimidin-4-amine
  • BIBU 1361
  • BIBU1361 (BIBU 1361 )
  • Pyrimido[5,4-d]pyrimidin-4-amine, N-(3-chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-
  • BIBU 1361二塩酸塩
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