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UK-371804

化学構造式
256477-09-5
CAS番号.
256477-09-5
化学名:
别名:
英語名:
UK-371804
英語别名:
UK-371804;Urokinase inhitibor 1;Urokinase inhibitor 1;UK-371804 (Urokinase inhitibor 1);UK 371804,UK-371804,Inhibitor,PAI-1,inhibit,Plasminogen activator inhibitor-1;N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine;Alanine, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-
CBNumber:
CB13160423
化学式:
C14H16ClN5O4S
分子量:
385.83
MOL File:
256477-09-5.mol

UK-371804 物理性質

貯蔵温度 :
Store at -20°C
溶解性:
DMSO:5.0(Max Conc. mg/mL);2.59(Max Conc. mM)
外見 :
A crystalline solid
色:
White to off-white
CAS データベース:
256477-09-5

安全性情報

UK-371804 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

UK-371804 化学特性,用途語,生産方法

説明

UK-371804 is a potent and selectiveurokinase-type plasmogen activator (uPA)inhibitor. It has excellent selectivityover tPA, plasmin, Factor IXa and Xa.In vitro, it is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound modelfollowing topical delivery, it is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. It has the potential for the treatment of chronic dermal ulcers.

参考文献

http://www.dcchemicals.com/product_show-UK_371804.html
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.

UK-371804 上流と下流の製品情報

原材料

準備製品

UK-371804 生産企業

Global( 61)Suppliers
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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BOC Sciences 		+1-631-485-4226
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career henan chemical co 		+86-0371-86658258 +8613203830695
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SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289
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Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
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InvivoChem 		+1-708-310-1919 +1-13798911105
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TargetMol Chemicals Inc. 		+1-781-999-5354
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ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 4692 58
Chengdu Henghui Pharm Tec Co. Ltd. 13540674322 15828370308
CHINA 121 55

  スペクトルデータ(1HNMR)

UK-371804(256477-09-5)1HNMR

256477-09-5()キーワード:

UK5099
  • 256477-09-5
  • UK-371804
  • Urokinase inhibitor 1
  • Urokinase inhitibor 1
  • UK-371804 (Urokinase inhitibor 1)
  • Alanine, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-
  • N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine
  • UK 371804,UK-371804,Inhibitor,PAI-1,inhibit,Plasminogen activator inhibitor-1
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