Cyclopentanone, 2,5-bis(2-thienylmethylene)-

Cyclopentanone, 2,5-bis(2-thienylmethylene)- 価格

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Cyclopentanone, 2,5-bis(2-thienylmethylene)- 化学特性,用途語,生産方法

一般的な説明

A cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC₅₀ = 8.4 μM), while exhibiting little activity against PPM1A even at concentrations as high as 100 μM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF₅₀ = 0.13, 0.17 & 0.48 μM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF₅₀ = 34 & >50 μM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.

Cyclopentanone, 2,5-bis(2-thienylmethylene)- 上流と下流の製品情報

原材料

準備製品

Cyclopentanone, 2,5-bis(2-thienylmethylene)- 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

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• 1087-07-6
• Cyclopentanone, 2,5-bis(2-thienylmethylene)-
• PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem