Cyclopentanone, 2,5-bis(2-thienylmethylene)-
- CAS No.
- 1087-07-6
- Chemical Name:
- Cyclopentanone, 2,5-bis(2-thienylmethylene)-
- Synonyms
- Cyclopentanone, 2,5-bis(2-thienylmethylene)-;PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem
- CBNumber:
- CB13178361
- Molecular Formula:
- C15H12OS2
- Molecular Weight:
- 272.39
- MDL Number:
- MOL File:
- 1087-07-6.mol
Last updated:2023-04-23 13:52:06
Cyclopentanone, 2,5-bis(2-thienylmethylene)- Chemical Properties,Uses,Production
General Description
A cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC50 = 8.4 μM), while exhibiting little activity against PPM1A even at concentrations as high as 100 μM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF50 = 0.13, 0.17 & 0.48 μM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF50 = 34 & >50 μM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.
Cyclopentanone, 2,5-bis(2-thienylmethylene)- Preparation Products And Raw materials
Raw materials
Preparation Products
Cyclopentanone, 2,5-bis(2-thienylmethylene)- Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |
Cyclopentanone, 2,5-bis(2-thienylmethylene)-
PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem
1087-07-6