Cyclopentanone, 2,5-bis(2-thienylmethylene)-

1087-07-6

CAS-Nr.: 1087-07-6

Englisch Name:: Cyclopentanone, 2,5-bis(2-thienylmethylene)-

Synonyma:: Cyclopentanone, 2,5-bis(2-thienylmethylene)-;PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem

CBNumber:: CB13178361

Summenformel:: C15H12OS2

Molgewicht:: 272.39

MOL-Datei:: 1087-07-6.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 2

Cyclopentanone, 2,5-bis(2-thienylmethylene)- Eigenschaften

Schmelzpunkt:: 226 °C

Siedepunkt:: 484.7±45.0 °C(Predicted)

Dichte: 1.363±0.06 g/cm3(Predicted)

storage temp.: +2C to +8C

Aggregatzustand: Yellow solid

Sicherheit

Cyclopentanone, 2,5-bis(2-thienylmethylene)- Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC₅₀ = 8.4 μM), while exhibiting little activity against PPM1A even at concentrations as high as 100 μM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF₅₀ = 0.13, 0.17 & 0.48 μM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF₅₀ = 34 & >50 μM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.

Cyclopentanone, 2,5-bis(2-thienylmethylene)- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Cyclopentanone, 2,5-bis(2-thienylmethylene)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 2)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

Cyclopentanone, 2,5-bis(2-thienylmethylene)-
PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem
1087-07-6