Fmoc-GGFG-Dxd

1599440-11-5

CAS番号.: 1599440-11-5

化学名:

别名:

英語名:: Fmoc-GGFG-Dxd

英語别名:: Fmoc-GGFG-Dxd;Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly-Fmoc;Glycinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-;(S)-2-[2-[2-(Fmoc-amino)acetamido]acetamido]-N-[2-[[[2-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]amino]-2-oxoethyl]-3-phenylpropanamide

CBNumber:: CB29806179

化学式:: C57H55FN8O12

分子量:: 1063.09

MOL File:: 1599440-11-5.mol

物理性質

安全性情報

用途語

生産企業 9

Fmoc-GGFG-Dxd 物理性質

比重(密度) :: 1.49±0.1 g/cm3(Predicted)

酸解離定数(Pka):: 10.61±0.46(Predicted)

安全性情報

Fmoc-GGFG-Dxd 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

Fmoc-GGFG-Dxd 化学特性,用途語,生産方法

説明

Fmoc-GGFG-Dxd, also known as N-((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)-2-hydroxyacetamide, is a brown powder. It is a hexacyclic chemical compound analogous to camptothecin with a triplet amino acid chain linked to a terminal Fmoc group. GGFG (glycyl-glycyl-phenylalanyl-glycine peptide could link exatecan derivative (DXd) through cysteine residues. DXd is highly membrane-permeable and exhibited strong bystander killing in-vitro co-culture of HER2 positive (KPL-4) and negative (MDA-MB-468) cells and in mice inoculated with a mixture of HER2 (+) and HER2 (?) cells.
説明図

Fmoc-GGFG-Dxd 上流と下流の製品情報

原材料

準備製品

Fmoc-GGFG-Dxd 生産企業

Global( 9)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Xilinglab Co., Ltd.	+8618381337976	bd@xilinglab.com	China	86	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
Shanghai Tekanbio Pharm-Tech Co., Ltd.	021-50896099 18017206244	sales@tekanbio.com	China	102	58
Abydos Scientific	025-84767922 18936879710	sales@abydoscientific.com	China	1012	58
Shochem(Shanghai)Co.,Ltd	+86-021-51783479 +86-13816874662	info@shochem.com	China	301	58
Shanghai Easy CDMO Co.,Ltd	021-61734564	August@easycdmo.com	China	10010	58
Shaoyuan Technology (Shanghai) Co., Ltd.	021-50795510 4000665055	sy-c6@accelachem.com	China	9979	58
Jilin Chinese Academy of Sciences-yanshen Technology	18143011203	ET-market@chemextension.com	China	41846	58
YJ Pharma	0513-15251351988 15251351988	3686954964@qq.com	China	262	58

1599440-11-5
Glycinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-
Fmoc-GGFG-Dxd
Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly-Fmoc
(S)-2-[2-[2-(Fmoc-amino)acetamido]acetamido]-N-[2-[[[2-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]amino]-2-oxoethyl]-3-phenylpropanamide