Fmoc-GGFG-Dxd

1599440-11-5

CAS-Nr.: 1599440-11-5

Englisch Name:: Fmoc-GGFG-Dxd

Synonyma:: Fmoc-GGFG-Dxd;Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly-Fmoc;Glycinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-;(S)-2-[2-[2-(Fmoc-amino)acetamido]acetamido]-N-[2-[[[2-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]amino]-2-oxoethyl]-3-phenylpropanamide

CBNumber:: CB29806179

Summenformel:: C57H55FN8O12

Molgewicht:: 1063.09

MOL-Datei:: 1599440-11-5.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 11

Fmoc-GGFG-Dxd Eigenschaften

Dichte: 1.49±0.1 g/cm3(Predicted)

pka: 10.61±0.46(Predicted)

Sicherheit

Fmoc-GGFG-Dxd Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Fmoc-GGFG-Dxd, also known as N-((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)-2-hydroxyacetamide, is a brown powder. It is a hexacyclic chemical compound analogous to camptothecin with a triplet amino acid chain linked to a terminal Fmoc group. GGFG (glycyl-glycyl-phenylalanyl-glycine peptide could link exatecan derivative (DXd) through cysteine residues. DXd is highly membrane-permeable and exhibited strong bystander killing in-vitro co-culture of HER2 positive (KPL-4) and negative (MDA-MB-468) cells and in mice inoculated with a mixture of HER2 (+) and HER2 (?) cells.

Fmoc-GGFG-Dxd Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Fmoc-GGFG-Dxd Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 11)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Xilinglab Co., Ltd.	+8618381337976	bd@xilinglab.com	China	86	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Shanghai Tekanbio Pharm-Tech Co., Ltd.	021-50896099 18017206244	sales@tekanbio.com	China	109	58
BioPharmaMatrix,Inc.	0510-86010668	sales@biopharmamatrix.com	China	4141	55
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	7268	58
Shochem(Shanghai)Co.,Ltd	+86-021-51783479 +86-13816874662	info@shochem.com	China	311	58
Shanghai Easy CDMO Co.,Ltd	021-61734564	August@easycdmo.com	China	10030	58
Shaoyuan Technology (Shanghai) Co., Ltd.	021-50795510 4000665055	sy-c6@accelachem.com	China	10000	58
Jilin Chinese Academy of Sciences-yanshen Technology	18143011203	ET-market@chemextension.com	China	25854	58
SuZhou GoodChemTech Co., Ltd	18136139868	jinlun@goodchemtech.cn	China	221	58

Glycinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-
Fmoc-GGFG-Dxd
Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly-Fmoc
(S)-2-[2-[2-(Fmoc-amino)acetamido]acetamido]-N-[2-[[[2-[[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-1,2,3,9,10,12,13,15-octahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]amino]-2-oxoethyl]-3-phenylpropanamide
1599440-11-5
C57H55FN8O12