BI-99179
BI-99179 物理性質
- 沸点 :
- 603.1±55.0 °C(Predicted)
- 比重(密度) :
- 1.25±0.1 g/cm3(Predicted)
- 酸解離定数(Pka):
- 15.72±0.40(Predicted)
- 外見 :
- Solid
- 色:
- White to off-white
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
BI-99179 価格
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BI-99179 化学特性,用途語,生産方法
Biochem/physiol Actions
BI 99179 is a non-cytotoxic (by LDH release; 30 μM, U937) orally available, brain-penetrant, highly potent and selective fatty acid synthase (FAS, FASN) inhibitor (IC50 = 79 nM by cell-free human FAS assay) with little or no inhibitory potency toward a panel of 30 receptors & channels (<20%>10 μM). BI 99179 inhibits cellular FAS activity in vitro (IC50 = 180 nM/human H1975, 600 nM/murine hypothalamic N-42 cells) and increases hypothalamic [malonyl-CoA] in rats in vivo (2 h post 10 mg/kg or 2-24 hr post 100 mg/kg p.o.). Note: adverse effects in rats are reported at day 4 (30 mg/kg) and day 9 (3 mg/kg).
BI-99179 上流と下流の製品情報
原材料
準備製品
BI-99179 生産企業
Global( 12)Suppliers
- 1291779-76-4
- BI-99179
- (1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-N-methyl-3-(propanoylamino)cyclopentane-1-carboxamide
- BI-99179
(BI99179)
- Cyclopentanecarboxamide, N-[4-(2-benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]-, (1R,3S)-