ChemicalBook >> CAS DataBase List >>BI-99179
BI-99179
- CAS No.
- 1291779-76-4
- Chemical Name:
- BI-99179
- Synonyms
- BI-99179;BI-99179 (BI99179);(1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-N-methyl-3-(propanoylamino)cyclopentane-1-carboxamide;Cyclopentanecarboxamide, N-[4-(2-benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]-, (1R,3S)-
- CBNumber:
- CB42627597
- Molecular Formula:
- C23H25N3O3
- Molecular Weight:
- 391.46
- MDL Number:
- MFCD25976795
- MOL File:
- 1291779-76-4.mol
Last updated:2024-07-02 08:55:08
| Boiling point | 603.1±55.0 °C(Predicted) |
|---|---|
| Density | 1.25±0.1 g/cm3(Predicted) |
| form | Solid |
| pka | 15.72±0.40(Predicted) |
| color | White to off-white |
| FDA UNII | S2JB42BBP5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
BI-99179 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2870 | BI 99179 ≥98% (HPLC) | 1291779-76-4 | 5MG | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2870 | BI 99179 ≥98% (HPLC) | 1291779-76-4 | 25MG | $380 | 2024-03-01 | Buy |
| Axon Medchem | Axon3181 | BI99179 99% | 1291779-76-4 | 25mg | $594 | 2021-12-16 | Buy |
| ChemScene | CS-0006139 | BI99179 99.78% | 1291779-76-4 | 50mg | $950 | 2021-12-16 | Buy |
| ChemScene | CS-0006139 | BI99179 99.78% | 1291779-76-4 | 100mg | $1500 | 2021-12-16 | Buy |
BI-99179 Chemical Properties,Uses,Production
Biochem/physiol Actions
BI 99179 is a non-cytotoxic (by LDH release; 30 μM, U937) orally available, brain-penetrant, highly potent and selective fatty acid synthase (FAS, FASN) inhibitor (IC50 = 79 nM by cell-free human FAS assay) with little or no inhibitory potency toward a panel of 30 receptors & channels (<20%>10 μM). BI 99179 inhibits cellular FAS activity in vitro (IC50 = 180 nM/human H1975, 600 nM/murine hypothalamic N-42 cells) and increases hypothalamic [malonyl-CoA] in rats in vivo (2 h post 10 mg/kg or 2-24 hr post 100 mg/kg p.o.). Note: adverse effects in rats are reported at day 4 (30 mg/kg) and day 9 (3 mg/kg).
BI-99179 Preparation Products And Raw materials
Raw materials
Preparation Products
BI-99179 Suppliers
Global( 9)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-020-82000279 18988968278 | sales@ubiochem.com | China | 4297 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9268 | 58 |
BI-99179
(1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-N-methyl-3-(propanoylamino)cyclopentane-1-carboxamide
BI-99179
(BI99179)
Cyclopentanecarboxamide, N-[4-(2-benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]-, (1R,3S)-
1291779-76-4