スルファメチゾール 化学特性,用途語,生産方法
外観
白色~ほとんど白色粉末~結晶
効能
抗菌薬, 葉酸合成阻害薬
説明
Sulfamethizole is a broad spectrum sulfonamide antibiotic (MIC
90s = 1.25-5,000 μg/ml against clinical isolates of
E. coli and
K. pneumoniae). It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.
使用
Sulfamethizole is a sulfonamide based antibiotic that exhibit bactericidal activities towards gram-negative bacteria. Sulfamehizole was shown to be effective in treating gram-negative Bacillus AmpC en
zyme in elderly patients with lower respiratory tract infection and as well as against microbs responsible for tuberculosis.
定義
ChEBI: A sulfonamide consisting of a 1,3,4-thiadiazole nucleus with a methyl substituent at C-5 and a 4-aminobenzenesulfonamido group at C-2.
世界保健機関(WHO)
Sulfamethizole, a sulfonamide anti-infective agent, was
introduced in 1953 for the treatment of bacterial infections. The importance of
sulfonamides has subsequently decreased as a result of increasing bacterial
resistance and their replacement by antibiotics which are generally more active
and less toxic. However sulfamethizole, which is rapidly eliminated, retains a place
in the treatment of urinary infections in some countries whereas in others its use has been discontinued.
一般的な説明
Sulfamethizole’splasma half-life is 2.5 hours. This compound is a white crystallinepowder soluble 1:2,000 in water.
空気と水の反応
Insoluble in water.
火災危険
Flammability data is lacking for SULFAMETHIZOLE. SULFAMETHIZOLE is probably non-flammable.
応用例(製薬)
2-Sulfanilamido-5-methyl-1,3,4-thiodiazole. A short-acting
sulfonamide (plasma half-life 2.5 h). Protein binding is c. 85%.
About 60% is excreted in the urine within 5 h. It was formerly
widely used in the treatment of urinary tract infection.
スルファメチゾール 上流と下流の製品情報
原材料
準備製品