설파메티졸
|
|
설파메티졸 속성
- 녹는점
- 210 °C
- 끓는 점
- 176°C (rough estimate)
- 밀도
- 1.4704 (rough estimate)
- 굴절률
- 1.6440 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 아세토니트릴(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 5.45(at 25℃)
- 색상
- 흰색에서 황백색까지
- 수용성
- 529mg/L(20℃)
- Merck
- 14,8916
- BRN
- 255002
- CAS 데이터베이스
- 144-82-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 43 | ||
안전지침서 | 36/37 | ||
WGK 독일 | 2 | ||
RTECS 번호 | WP0875000 | ||
HS 번호 | 2935904000 | ||
유해 물질 데이터 | 144-82-1(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: 3500mg/kg |
설파메티졸 C화학적 특성, 용도, 생산
개요
Sulfamethizole is a broad spectrum sulfonamide antibiotic (MIC90s = 1.25-5,000 μg/ml against clinical isolates of E. coli and K. pneumoniae). It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.용도
Sulfamethizole is a sulfonamide based antibiotic that exhibit bactericidal activities towards gram-negative bacteria. Sulfamehizole was shown to be effective in treating gram-negative Bacillus AmpC en zyme in elderly patients with lower respiratory tract infection and as well as against microbs responsible for tuberculosis.정의
ChEBI: A sulfonamide consisting of a 1,3,4-thiadiazole nucleus with a methyl substituent at C-5 and a 4-aminobenzenesulfonamido group at C-2.World Health Organization (WHO)
Sulfamethizole, a sulfonamide anti-infective agent, was introduced in 1953 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. However sulfamethizole, which is rapidly eliminated, retains a place in the treatment of urinary infections in some countries whereas in others its use has been discontinued.일반 설명
Sulfamethizole’splasma half-life is 2.5 hours. This compound is a white crystallinepowder soluble 1:2,000 in water.공기와 물의 반응
Insoluble in water.화재위험
Flammability data is lacking for SULFAMETHIZOLE. SULFAMETHIZOLE is probably non-flammable.Pharmaceutical Applications
2-Sulfanilamido-5-methyl-1,3,4-thiodiazole. A short-acting sulfonamide (plasma half-life 2.5 h). Protein binding is c. 85%. About 60% is excreted in the urine within 5 h. It was formerly widely used in the treatment of urinary tract infection.설파메티졸 준비 용품 및 원자재
원자재
준비 용품
설파메티졸 공급 업체
글로벌( 215)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29825 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24295 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15395 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 |
contact@labnetwork.com | China | 19994 | 58 |
PT CHEM GROUP LIMITED | |
peter68@ptchemgroup.com | China | 35426 | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 |
admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com | China | 12272 | 58 |
설파메티졸 관련 검색:
설파닐아미드
TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE
SULFAMETHIZOLE
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE
1-Boc-4-(aminomethyl)piperidine
tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate
BOC-3-CARBOXYMETHYL-1-PHENYL-1,3,8-TRIAZASPIRO[4 5]DECAN-4-ONE
4-(AMINO-METHOXYCARBONYL-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(S)-A-FMOC-D-BOC-4-PIPERIDYLGLYCINE
1-BOC-4-(AMINOCARBOXYMETHYL)PIPERIDINE
glybuthiazol
1-T-BOC-PIPERIDINE-4-SPIRO-5'-[1',3'-BIS-T-BOC]-HYDANTOIN
N-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YLMETHYLPIPERIDINE-4-CARBOXYLIC ACID
(R)-N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N'-T-BUTYLOXYCARBONYL-4-PIPERIDYLGLYCINE
Phthalylsulfamethizol
(S)-4-(AMINO-METHOXYCARBONYL-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
3-[4-(5-ETHYL-[1,3,4]THIADIAZOL-2-YLSULFAMOYL)-PHENYLCARBAMOYL]-ACRYLIC ACID
SULFAETHIDOLE SODIUM