A54556A (〜90%)

A54556A (〜90%) 化学構造式
95398-45-1
CAS番号.
95398-45-1
化学名:
A54556A (〜90%)
别名:
A54556A (〜90%)
英語名:
A 54556A
英語别名:
A 54556A;A 54556A (~90%);Antibiotic A-54556A;PubChem ID: 24767779;L-Proline, N-[(2E,4E,6E)-1-oxo-2,4,6-octatrien-1-yl]-L-phenylalanyl-L-seryl-L-prolyl-N-methyl-L-alanyl-L-alanyl-4-methyl-, (6→2)-lactone, (4R)-
CBNumber:
CB42744531
化学式:
C38H50N6O8
分子量:
718.839
MOL File:
95398-45-1.mol

A54556A (〜90%) 物理性質

融点 :
>180oC (dec.)
沸点 :
1086.9±65.0 °C(Predicted)
比重(密度) :
1.28±0.1 g/cm3(Predicted)
貯蔵温度 :
Amber Vial, Refrigerator
溶解性:
クロロホルム(微量)、DMSO(微量)、メタノール(微量)
外見 :
個体
酸解離定数(Pka):
12.80±0.46(Predicted)
色:
淡い黄色から薄茶色
安定性::
光に敏感

安全性情報

A54556A (〜90%) 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCA101055 A54556A (〜90%)
A 54556A (?90%)
95398-45-1 0.5mg ¥113700 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCA101055 A54556A (〜90%)
A 54556A (?90%)
95398-45-1 1mg ¥202800 2024-03-01 購入

A54556A (〜90%) 化学特性,用途語,生産方法

説明

A-54556A is an acyldepsipeptide (ADEP) antibiotic that has been found in Streptomyces hawaiiensis. It is active against B. subtilis, S. pyogenes, and E. faecalis, as well as penicillin-resistant S. pneumoniae, vancomycin-resistant E. faecium, and methicillin-resistant S. aureus (MRSA; IC50s = 0.2, 0.4, 0.4, 1.6, 0.4, and 6.3 μg/ml, respectively). It binds to and activates caseinolytic protease P (ClpP), inducing degradation of β-casein by the B. subtilis ClpP in an ATPase-independent manner when used at concentrations of 2.5 and 5 μg/ml.

使用

A 54556A is an unusual depsipeptide isolated from Streptomyces hawaiiensis by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556A is potently active against Gram positive and Gram negative bacteria, including MRSA. A 54556A was the original lead structure of the recently re-discovered acyldepsipeptide (ADEP) antibiotics that act by activating and disregulating Clp-family proteins. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.

A54556A (〜90%) 上流と下流の製品情報

原材料

準備製品


A54556A (〜90%) 生産企業

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BOC Sciences
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ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
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MedBioPharmaceutical Technology Inc 021-69568360 18916172912
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Shanghai Tachizaki Biomedical Research Center 18014399201
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ApexBio Technology --
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  • 95398-45-1
  • A 54556A
  • PubChem ID: 24767779
  • A 54556A (~90%)
  • Antibiotic A-54556A
  • L-Proline, N-[(2E,4E,6E)-1-oxo-2,4,6-octatrien-1-yl]-L-phenylalanyl-L-seryl-L-prolyl-N-methyl-L-alanyl-L-alanyl-4-methyl-, (6→2)-lactone, (4R)-
  • A54556A (〜90%)
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