A 54556A Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
A-54556A is an acyldepsipeptide (ADEP) antibiotic that has been found in
Streptomyces hawaiiensis. It is active against
B. subtilis, S. pyogenes, and
E. faecalis, as well as penicillin-resistant
S. pneumoniae, vancomycin-resistant
E. faecium, and methicillin-resistant
S. aureus (MRSA; IC
50s = 0.2, 0.4, 0.4, 1.6, 0.4, and 6.3 μg/ml, respectively). It binds to and activates caseinolytic protease P (ClpP), inducing degradation of β-casein by the
B. subtilis ClpP in an ATPase-independent manner when used at concentrations of 2.5 and 5 μg/ml.
Verwenden
A 54556A is an unusual depsipeptide isolated from Streptomyces hawaiiensis by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556A is potently active against Gram positive and Gram negative bacteria, including MRSA. A 54556A was the original lead structure of the recently re-discovered acyldepsipeptide (ADEP) antibiotics that act by activating and disregulating Clp-family proteins. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.
A 54556A Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
