ナビロン
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- CAS番号.
- 51022-71-0
- 化学名:
- ナビロン
- 别名:
- 英語名:
- NABILONE-DEA SCHEDULE II
- 英語别名:
- Nabilone;lilly109514;Nabilone solution;trans-(+-)-hydroxy-;NABILONE-DEA SCHEDULE II;d)pyran-9-one,3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-9h-dibenzo(;(6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6,6a,7,8,10,10a-hexahydrobenzo[c]chromen-9-one;trans-6,6-Dimethyl-3-(1,1-dimethylheptyl)-1-hydroxy-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one;9H-Dibenzo[b,d]pyran-9-one, 3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-, (6aR,10aR)-rel-;NabiloneQ: What is
Nabilone Q: What is the CAS Number of
Nabilone Q: What is the storage condition of
Nabilone Q: What are the applications of
Nabilone
- CBNumber:
- CB4504001
- 化学式:
- C24H36O3
- 分子量:
- 372.54
- MOL File:
- 51022-71-0.mol
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ナビロン 物理性質
- 融点 :
- 155-156°C
- 沸点 :
- 457.4±45.0 °C(Predicted)
- 比重(密度) :
- 1.029±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO: ~18 mg/mL、可溶
- 外見 :
- 個体
- 酸解離定数(Pka):
- pKa in 66% DMF: 13.5(at 25℃)
- 色:
- 白い
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
 
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| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
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P264, P270, P301+P312, P330, P501 |
| H336 |
眠気やめまいのおそれ |
特定標的臓器毒性、単回暴露； 麻酔作用 |
3 |
警告 |
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P261, P271, P304+P340, P312,P403+P233, P405, P501 |
| H361 |
生殖能または胎児への悪影響のおそれの疑い |
生殖毒性 |
2 |
警告 |
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P201, P202, P281, P308+P313, P405,P501 |
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| 注意書き |
| P202 |
全ての安全注意を読み理解するまで取り扱わないこ と。 |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時に、飲食または喫煙をしないこ と。 |
| P301+P312 |
飲み込んだ場合：気分が悪い時は医師に連絡する こと。 |
| P308+P313 |
暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。 |
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ナビロン 化学特性,用途語,生産方法
効能
制吐薬, マイナートランキライザー, カンナビノイド受容体作動薬
化学的特性
White to Off-White Solid
使用
A labelled synthetic cannabinoid with antiemetic, antiglaucoma, and CNS activity. Antiemetic.
Controlled substance (hallucinogen).
世界保健機関（WHO）
Nabilone is a structural analogue of dronabinol (delta-9-
tetrahydrocannabinol), the major active component of cannabis.
薬理学
Nabilone is a synthetic analogue of THC that has shown particular promise in laboratory models of CUD. Nabilone has better bioavailability, a longer duration of action, and lower abuse liability than dronabinol, and since it produces unique urinary metabolites, researchers can distinguish cannabis use from medication compliance. Haney et al. investigated two doses of nabilone in the human laboratory and showed that this medication significantly decreased a laboratory measure of cannabis relapse and improved mood symptoms of withdrawal, such as irritability. Further, the higher nabilone dose also decreased craving for cannabis, increased quality of sleep, and improved food intake. In 2016, Herrmann et al. used a similar human laboratory design to test the combination of nabilone and the GABAA agonist, zolpidem, hypothesizing that combining nabilone with an efficacious sleep medication may produce more robust reductions in cannabis withdrawal and relapse than those observed with nabilone alone by Haney et al. Zolpidem was also tested alone, and although it improved sleep during cannabis withdrawal relative to placebo, it did not reduce relapse. The combination of zolpidem and nabilone provided a more comprehensive reduction in withdrawal symptoms (negative mood, anorexia, disrupted sleep) and also reduced cannabis relapse. The authors suggest that the majority of these effects are attributable to nabilone. These laboratory findings await confirmation in clinical treatment settings, but the results of these studies demonstrate that nabilone holds considerable promise for CUD treatment.
ナビロン 上流と下流の製品情報
原材料
準備製品
51022-71-0(ナビロン)キーワード:
- 51022-71-0
- NABILONE-DEA SCHEDULE II
- d)pyran-9-one,3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-9h-dibenzo(
- lilly109514
- trans-(+-)-hydroxy-
- Nabilone
- trans-6,6-Dimethyl-3-(1,1-dimethylheptyl)-1-hydroxy-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one
- Nabilone solution
- (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6,6a,7,8,10,10a-hexahydrobenzo[c]chromen-9-one
- 9H-Dibenzo[b,d]pyran-9-one, 3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-, (6aR,10aR)-rel-
- NabiloneQ: What is
Nabilone Q: What is the CAS Number of
Nabilone Q: What is the storage condition of
Nabilone Q: What are the applications of
Nabilone