オルトぎ酸トリメチル 化学特性,用途語,生産方法
外観
無色~ほとんど無色, 澄明の液体
溶解性
エタノール及びアセトンに極めて溶けやすく、水で分解する。
用途
医薬品、化粧品の製造原料、染料
説明
Trimethyl orthoformate is an effective solvent for thallium(III) nitrate-mediated oxidations. It undergoes acid catalyzed reaction with 6-(N-D-ribitylanilino) uracils to form 8-demethyl-8-hydroxy-5-deazariboflavins.
化学的特性
Colorless liquid. Slightly soluble in water, miscible with alcohol and oils.
Very diffusive, ethereal, pungent or nauseating odor, pleasant in dilution, slightly wineyfruity, Brandy-like.
Sweet taste in concentrations below 100 ppm.
Barely perceptible at 10 ppm.
使用
Trimethyl Orthoformate is the most simple orthoester. Used in organic synthesis as a reagent for introducing a protecting group for aldehydes and in the creation of methoxymethylene groups and heterocyclic ring systems.
主な応用
Trimethyl orthoformate was used as dehydrating agent in the preparation of surface-modified colloidal silica nanoparticles.
MOM protection of Diols using Trimethyl Orthoformate
N-Formylation of Amino Acid Esters
一般的な説明
Trimethyl orthoformate is an effective solvent for thallium(III) nitrate-mediated oxidations. It undergoes acid catalyzed reaction with 6-(
N-D-ribitylanilino) uracils to form 8-demethyl-8-hydroxy-5-deazariboflavins.
安全性プロファイル
A skin and eye irritant.
A very dangerous fire hazard when exposed
to heat or flame; can react with oxidizing
materials. Hazardous to prepare. To fight
fire, use CO2, fog, haze. When heated to
decomposition it emits acrid smoke and
irritating fumes. See also ESTERS.
予防処置
Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with acids and strong oxidizing agents.
参考文献
Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
P. G. M. Wuts, in Greene's Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
A Facile Procedure for the Synthesis of N-Formyl Amino Acid Esters
T. Chancellor, C. Morton, Synthesis 1994, 10, 1023.
オルトぎ酸トリメチル 上流と下流の製品情報
原材料
準備製品
6-bromoquinolin-4(3H)-one
6-ブロモ-4-クロロキノリン
4-メトキシ-3,6-ジヒドロ-2H-ピラン
N-メチル-4-(トリフルオロメチル)アニリン
ピペミド酸
メタンスルホン酸メチル
N-メチル-3-メトキシアニリン
N-メチル-p-アニシジン
ETHYL 5-AMINO-1-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLATE
N-Boc-5,6,7,8-tetrahydro-3-methoxy-[1,2,4]triazolo[4,3-A]pyrazine ,98%
トリフルオロ酢酸メチル
4,7-ジメトキシ-1,10-フェナントロリン
Tetramethoxyethylene
ブロモホルム
(4aR,8R,9cS)-3,5-ジメトキシ-12-メチル-4a,8,9,9c-テトラヒドロ-8,9c-(イミノエタノ)フェナントロ[4,5-bcd]フラン
2-メチルウンデカナールジメチルアセタール
D-(-)-酒石酸ジメチル
p-アニスアルデヒドジメチルアセタール
6,7-ジヒドロ-2-フェニル-5H-ピロロ[2,1-c]-1,2,4-トリアゾリウムクロリド, min. 98%
BASIC RED 12