N-[2-[3-[(1,1-ジメチルエチル)アミノ]-2-ヒドロキシプロポキシ]フェニル]-2-フランカルボアミド 化学特性,用途語,生産方法
Originator
Ancarolol,ZYF Pharm Chemical
Manufacturing Process
A mixture of 23 g of 2'-(2,3-epoxypropoxy)-furan-2-carboxylic acid anilide,
7.3 g of t-butylamine and 50 ml of isopropanol is boiled under reflux for 10
hours. On cooling, 2'-(2-hydroxy-3-t-butylaminopropoxy)-furan-2-carboxylic
acid anilide (ancarolol) crystallizes out from the solution. The
chromatographically pure base is obtained in the form of a white solid of
melting point 112°-113°C by recrystallization from ethyl acetate. The yield is
12 g. The colorless, crystalline base is dissolved in alcohol, alcoholic HCl is
added and the hydrochloride is induced to crystallize by adding ether
dropwise. After isolation, the salt is recrystallized again from ethanol. This
gives 10 g of the hydrochloride, melting point 189°-191°C.
Therapeutic Function
Beta-adrenergic blocker
N-[2-[3-[(1,1-ジメチルエチル)アミノ]-2-ヒドロキシプロポキシ]フェニル]-2-フランカルボアミド 上流と下流の製品情報
原材料
準備製品