안카롤롤

안카롤롤
안카롤롤 구조식 이미지
카스 번호:
75748-50-4
한글명:
안카롤롤
동의어(한글):
안카롤롤
상품명:
Ancarolol
동의어(영문):
Ancarolol;N-[2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]furan-2-carboxamide;N-[2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-2-furancarboxamide;2-Furancarboxamide, N-[2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-
CBNumber:
CB61117659
분자식:
C18H24N2O4
포뮬러 무게:
332.39
MOL 파일:
75748-50-4.mol

안카롤롤 속성

끓는 점
433.7±45.0 °C(Predicted)
밀도
1.183±0.06 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
DMSO에 용해됨
산도 계수 (pKa)
12.26±0.70(Predicted)

안전

안카롤롤 C화학적 특성, 용도, 생산

Originator

Ancarolol,ZYF Pharm Chemical

Manufacturing Process

A mixture of 23 g of 2'-(2,3-epoxypropoxy)-furan-2-carboxylic acid anilide, 7.3 g of t-butylamine and 50 ml of isopropanol is boiled under reflux for 10 hours. On cooling, 2'-(2-hydroxy-3-t-butylaminopropoxy)-furan-2-carboxylic acid anilide (ancarolol) crystallizes out from the solution. The chromatographically pure base is obtained in the form of a white solid of melting point 112°-113°C by recrystallization from ethyl acetate. The yield is 12 g. The colorless, crystalline base is dissolved in alcohol, alcoholic HCl is added and the hydrochloride is induced to crystallize by adding ether dropwise. After isolation, the salt is recrystallized again from ethanol. This gives 10 g of the hydrochloride, melting point 189°-191°C.

Therapeutic Function

Beta-adrenergic blocker

안카롤롤 준비 용품 및 원자재

원자재

준비 용품


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