N6-benzoyl-Cyclic AMP (sodium salt) 化学特性,用途語,生産方法
説明
N
6-benzoyl-Cyclic AMP (6-Bnz-cAMP) is a cell permeable cAMP analog that selectively activates PKA over exchange proteins activated by cAMP (Epac1 and 2, also known as RAPGEF3 and 4). It binds the AI and AII subunits of PKA with pK
i values of 4.0 and 3.8, respectively, whereas it binds Epac1 with a pK
i value of 1.3. 6-Bnz-cAMP stimulates the phosphorylation of the PKA substrate CREB but does not activate the Epac target Rap1. It can act synergistically with Epac-selective activators, such as 8-pCPT-2’-O-Me-cAMP .
N6-benzoyl-Cyclic AMP (sodium salt) 上流と下流の製品情報
原材料
準備製品