フタル酸ジブチル 化学特性,用途語,生産方法
外観
無色澄明の液体
定義
本品は、フタル酸とブタノール(*)のジエステルであり、次の化学式で表される。
参照表示名称：ブタノール
溶解性
水に微溶 (0.01g/100ml水, 25℃)。エタノールに極めて溶けやすく、アセトンに溶け、水にほとんど溶けない。
解説
1,2-benzenedicarboxylic acid dibutyl ester．C16H22O4(278.34)．フタル酸ジブチル, 略称DBP．無水フタル酸とブタノールとを酸の存在下に加熱してエステル化すると得られる．無色の油状液体．凝固点－35 ℃．沸点339 ℃，227～235 ℃(4.9 kPa)．d251.042．n20D1.4926．粘度20.3 cP(20 ℃)．蒸気圧146 Pa(150 ℃)．有機溶媒に易溶，水に不溶．可塑剤として用いられる．塩化ビニル，そのほかのビニル系樹脂と相容性がよい．可塑剤としては安価であるが，揮発性が大きく，耐油性の点でもフタル酸ビス(2-エチルヘキシル)に劣る．
森北出版「化学辞典（第2版）
用途
角質溶解薬 殺菌薬 植物成長調整剤 制瀉薬 代謝産物,食品?飲料用,医薬?化粧品配合原料,醸造工程添加剤,金属メッキ用
用途
高沸点溶剤。合成樹脂可塑剤。
用途
環境試料中のフタル酸エステルの分析（HPLC）用標準品、GC-MS分析標準品。
用途
可塑剤、染料、顔料、塗料、インク、接着剤、潤滑剤
用途
可塑剤、接着剤、塗料原料
化粧品の成分用途
可塑剤、溶剤、香料
主な用途／役割
エマルション系接着剤の可塑剤、エポキシ樹脂系接着剤の希釈剤として使用される。
説明
Dibutyl phthalate is included as an insect repellent in
some aerosol sprays used to treat flystrike in sheep. It is colorless oily liquid with a very weak aromatic odor.
化学的特性
Dibutyl phthalate occurs as an odorless, oily, colorless, or very slightly yellow-colored, viscous liquid.
物理的性質
Colorless to pale yellow, oily, viscous liquid with a mild, aromatic odor
使用
Dibutyl phthalate is used in plasticizers, cosmetics, safety glass, insecticides, printing inks, paper coatings, adhesives, elastomers and explosives; solvent in
polysulfide dental impression materials; solvent for perfume oils; perfume fixative; textile lubricating agent; solid rocket propellent; emollient in aerosol antiperspirants; insect repeller; plasticizer in various plastic materials.
調製方法
Dibutyl phthalate is produced from n-butanol and phthalic anhydride in an ester formation reaction.
定義
ChEBI: Dibutyl phthalate is a phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans. It has a role as an environmental contaminant, a teratogenic agent, a plasticiser, a metabolite and an EC 3.2.1.20 (alpha-glucosidase) inhibitor. It is a phthalate ester and a diester. It is functionally related to a butan-1-ol.
一般的な説明
Dibutyl phthalate is a colorless oily liquid. Dibutyl phthalate is insoluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Since Dibutyl phthalate is a liquid Dibutyl phthalate can easily penetrate the soil and contaminate groundwater and nearby streams. Dibutyl phthalate is combustible though Dibutyl phthalate may take some effort to ignite. Dibutyl phthalate is used in paints and plastics and as a reaction media for chemical reactions.
空気と水の反応
Insoluble in water.
反応プロフィール
Dibutyl phthalate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Avoid contact with strong oxidizing agents and strong bases. Will not polymerize. [USCG, 1999]. Can generate electrostatic charges. [Handling Chemicals Safely 1980. p. 250].
健康ハザード
The toxicity of this compound is very low. Inhumans, oral intake of dibutyl phthalate at adose level of 150 mg/kg may cause nausea,vomiting, dizziness, hallucination, distortedvision, lacrimation, and conjunctivitis withprompt recovery. It metabolizes to monobutylester and phthalic acid and is excreted in urine.The inhalation toxicity should be insignificantbecause of its negligible low vapor pressure[<0.1 torr at 20°C (68°F)]. However, expo sure to its mist or aerosol can cause irritationof eyes and mucous membranes
LD50 value, oral (mice): 5300 mg/kg.
火災危険
Combustible.
応用例（製薬）
Dibutyl phthalate is used in pharmaceutical formulations as a plasticizer in film-coatings. It has been evaluated as a pore-forming agent in novel delivery systems.It is also used extensively as a solvent, particularly in cosmetic formulations such as antiperspirants, hair shampoos, and hair sprays. In addition to a number of industrial applications, dibutyl phthalate is used as an insect repellent, although it is not as effective as dimethyl phthalate.
接触アレルゲン
It is mainly used as a nonreactive epoxy diluent.
安全性プロファイル
Moderately toxic by
intraperitoneal and intravenous routes.
Mildly toxic by ingestion. Human systemic
eye effects by ingestion, hallucinations,
dstorted perceptions, nausea or vomiting,
and kidney, ureter, or bladder changes.
Experimental teratogenic and reproductive
effects. Mutation data reported.
Combustible when exposed to heat or
flame; can react with oxidizing materials.
Violent reaction with Cl2. Incompatible with
chlorine. To fight fire, use CO2, dry
chemical. When heated to decomposition it
emits acrid smoke and fumes. See also
ESTERS, PHTHALIC ACID, and n
BUTYL ALCOHOL.
安全性
Dibutyl phthalate is generally regarded as a relatively nontoxic material, although it has occasionally been reported to cause hypersensitivity reactions. It is widely used in topical cosmetic and some oral pharmaceutical formulations.
LD50 (mouse, IV): 0.72g/kg
LD50 (mouse, oral): 5.3g/kg
LD50 (rat, oral): 8.0g/kg
LD50 (rat, IP): 3.05mL/kg
貯蔵
Dibutyl phthalate should be stored in a well-closed container in a cool, dry, location. Containers may be hazardous when empty since they can contain product residues such as vapors and liquids.
純化方法
Wash DBP with H2O (to free it from alcohol), then dilute NaOH (to remove any butyl hydrogen phthalate or acid), aqueous NaHCO3 (charcoal), then distilled water. Dry it (CaCl2), distil it at 10torr or less, and store it in a desiccator over P2O5. [Beilstein 9 II 586, 9 III 4102, 9 IV 3175.]
不和合性
Dibutyl phthalate reacts violently with chlorine. It also reacts with oxidizing agents, acids, bases, and nitrates.
規制状況(Regulatory Status)
Included in the FDA Inactive Ingredients Database (oral capsules, delayed action, enteric coated, and controlled release tablets). Included in nonparenteral medicines licensed in the UK (oral capsules, tablets, granules; topical creams and solutions).
フタル酸ジブチル 上流と下流の製品情報
原材料
準備製品