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XAP044

化学構造式
196928-50-4
CAS番号.
196928-50-4
化学名:
别名:
英語名:
XAP044
英語别名:
XAP044;XAP044, 10 mM in DMSO;mGlu7 Antagonist, XAP044;7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one;7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-iodophenoxy)-;XAP-044,mGlu7,XAP044,neurotransmission,brain exposure,CNS,inhibit,mGluR,antidepressant,Metabotropic glutamate receptors,wide spectrum,anti-stress,Inhibitor,anxiolytic-like,XAP 044
CBNumber:
CB73152769
化学式:
C15H9IO4
分子量:
380.13
MOL File:
196928-50-4.mol
MSDS File:
SDS

XAP044 物理性質

沸点 :
485.7±45.0 °C(Predicted)
比重(密度) :
1.853±0.06 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
≤10mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
外見 :
crystalline solid
酸解離定数(Pka):
6.70±0.20(Predicted)
色:
white to beige

安全性情報

XAP044 価格 もっと(6)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01FLC511616
7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one 		196928-50-4 250mg ￥175600 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01FLC511616
7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one 		196928-50-4 500mg ￥311900 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01TOC5248
XAP 044 		196928-50-4 10mg ￥71000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC5248
XAP 044 		196928-50-4 50mg ￥300000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01FLC511616
7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one 		196928-50-4 1g ￥553100 2021-03-23 購入

XAP044 化学特性,用途語,生産方法

説明

XAP044 is an antagonist of the metabotropic glutamate (mGlu) receptor 7 (mGluR7), inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC50 value of 88 nM. This effect is absent in mGluR7-deficient mice. XAP044 demonstrates good brain penetrance, producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests.

使用

XAP 044 is a potent mGlu7 antagonist used in the treatment of anxiety and depression in mice (1,2). Applications towards stress, autism and drug abuse are also potential uses.

XAP044 上流と下流の製品情報

原材料

準備製品

XAP044 生産企業

Global( 46)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32159 58
Aladdin Scientific
tp@aladdinsci.com United States 52924 58
BOC Sciences 1-631-485-4226; 16314854226
 info@bocsci.com United States 14055 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9804 58
Block Chemical Technology (Shanghai) Co., LTD 021-20432219 13918097649
 li_jinfei@acblock-lab.com China 9439 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551
 15151849396@163.com China 998 58
Energy Chemical 021-58432009 400-005-6266
 marketing1@energy-chemical.com China 44811 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
3477467573@qq.com China 8617 58
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24641 58

  スペクトルデータ(1HNMR)

XAP044(196928-50-4)1HNMR
  • 196928-50-4
  • XAP044
  • 7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
  • 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-iodophenoxy)-
  • 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
  • XAP-044,mGlu7,XAP044,neurotransmission,brain exposure,CNS,inhibit,mGluR,antidepressant,Metabotropic glutamate receptors,wide spectrum,anti-stress,Inhibitor,anxiolytic-like,XAP 044
  • XAP044, 10 mM in DMSO
  • mGlu7 Antagonist, XAP044
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