1-(tert-ブトキシカルボニル)ピペラジン
1-(tert-ブトキシカルボニル)ピペラジン 物理性質
- 融点 :
- 43-47 °C(lit.)
- 沸点 :
- 98-100
- 比重(密度) :
- 1.030±0.06 g/cm3(Predicted)
- 闪点 :
- >230 °F
- 貯蔵温度 :
- Keep in dark place,Inert atmosphere,2-8°C
- 溶解性:
- Soluble in DMSO
- 酸解離定数(Pka):
- 8.45±0.10(Predicted)
- 外見 :
- 低融点結晶質量
- 色:
- 白色～淡黄色
- 水溶解度 :
- 酢酸エチル、メタノール、水に可溶。
- Sensitive :
- Air Sensitive
- BRN :
- 879985
- InChIKey:
- CWXPZXBSDSIRCS-UHFFFAOYSA-N
- CAS データベース:
- 57260-71-6(CAS DataBase Reference)
- NISTの化学物質情報:
- T-butyl 1-piperaziencarboxylate(57260-71-6)
1-(tert-ブトキシカルボニル)ピペラジン 価格
もっと(31)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBAM-1697 |
t-Butyl piperazine-1-carboxylate |
57260-71-6 |
5g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01APOOR1731 |
Piperazine, N1-BOC protected |
57260-71-6 |
100g |
￥8600 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01APOOR1731 |
Piperazine, N1-BOC protected |
57260-71-6 |
500g |
￥47500 |
2023-06-01 |
購入 |
|
東京化成工業
|
B2415 |
1-(tert-ブトキシカルボニル)ピペラジン >98.0%(GC)(T)
1-(tert-Butoxycarbonyl)piperazine
>98.0%(GC)(T) |
57260-71-6 |
5g |
￥7000 |
2024-03-01 |
購入 |
|
東京化成工業
|
B2415 |
1-(tert-ブトキシカルボニル)ピペラジン >98.0%(GC)(T)
1-(tert-Butoxycarbonyl)piperazine
>98.0%(GC)(T) |
57260-71-6 |
25g |
￥24400 |
2024-03-01 |
購入 |
1-(tert-ブトキシカルボニル)ピペラジン 化学特性,用途語,生産方法
外観
白色～うすい黄色～うすい黄赤色粉末～結晶
溶解性
水、エタノール及びアセトンに溶ける。
用途
有機合成原料。
用途
医薬中間体.
化学的特性
Waxy Solid
使用
1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.
主な応用
Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.
一般的な説明
1-Boc-piperazine is an
N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K
3PO
4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free
N-Boc protection catalyzed by iodine.
1-(tert-ブトキシカルボニル)ピペラジン 上流と下流の製品情報
原材料
準備製品
1-(tert-ブトキシカルボニル)ピペラジン 生産企業
Global( 845)Suppliers
1-(tert-ブトキシカルボニル)ピペラジン スペクトルデータ(1HNMR、FT-IR、IR、Raman)
57260-71-6(1-(tert-ブトキシカルボニル)ピペラジン)キーワード:
- 57260-71-6
- 1-Boc-piperazine,99%
- 1-(tert-Butyloxycarbonyl)piperazine
- 1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
- 1-Piperazinecarboxylic Acid tert-Butyl Este
- N-(tert-Butoxycarbonyl)piperazine 98%
- Piperazine, N1-BOC protected
- tert-Butyl 2-piperazinecarboxylate
- N-(T-BUTYLOXYCARBONYL)-PIPERAZINE
- BUTTPARK 52\11-35
- BOC-PAZ
- 1-(tert-Butoxycarbonyl)piperazine~tert-Butyl 1-piperazinecarboxylate
- 1-BOC-PIPERAZINE, PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- 1-N-BOC-PIPERAZINE 99+%
- Piperazine, N1-BOC protected 98%
- 1-BOC-PIPERAZINE hydrochloride
- N-Boc-piperazine [N-(tert-Butoxycarbonyl)-piperazine]
- 1-Boc-piperazine >=98.0% (GC)
- 1-Boc-piperazine 97%
- N - bok - piperazine
- 1-Boc-piperazine≥ 99%(GC)
- tert-Butyl 1-piperazinecarboxyl
- N-Boc-piperazine hydrochloride
- 1-Boc-piperazine ,98%
- tert-Butyl 1-piperazinecarboxylate,97%
- tert-Butyl 1-piperazinecarboxylate，1-N-Boc-Piperazine
- 1-Boc-piperazine,tert-Butyl piperazine-1-carboxylate
- tert-butyl piperazine-1-carboxylate(SALTDATA: FREE)
- t-Butyl 1-piperazincarboxylate
- TERT-BUTYL N-PIPERAZINE
- TERT-BUTYL TETRAHYDROPYRAZINE-1(2H)-CARBOXYLATE
- 1-(tert-ブトキシカルボニル)ピペラジン
- 1-Boc-ピペラジン
- ピペラジン-1-カルボン酸 tert-ブチル
- N‐BOC‐ピペラジン
- N-BOC-ピペラジン
- tert-ブチル ピペラジン-1-カルボキシラート