ロフラミコイン

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ロフラミコイン 化学特性,用途語,生産方法

合成

For Rychnovsky and co-worker’s synthesis of roflamycoin (45), the hemiketal-pyran linkage required differential substitution (Scheme 9) and demonstrated the power of the sequential double addition strategy.14 Treatment of bis-epoxide S,S-4 with a stoichiometric amount of (benzyloxy)methyllithium 38 and BF3?OEt2 in THF at –78 °C provided monoaddition adduct 39, which was then treated with the organolithium formed from transmetallation of 2,2-bis-(tributyltin)dithiane 40. This single-pot procedure afforded dithiane diol 41 in 56% overall yield. Subsequent acetonide formation and transmetallation provided a competent nucleophile for direct displacement of dibromide 42, which itself was derived from dichlorodiol R,R-3. The resulting bis-acetonide (43) was obtained in 60% overall yield and provided a rapid access to tris-acetonide 44, a key intermediate for the synthesis of the hemiketal-pyran moiety of 45. Similar sequential addition strategies have proven to be useful as well.

ロフラミコイン 上流と下流の製品情報

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準備製品

ロフラミコイン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Zhejiang Huida Biotech Co., LTD	0571-89903882 13626641628	jiangnan@huidabiotech.com	China	3656	58
Zhejiang Huida Biotech Co., LTD	0571-0571-89903882 15990081639	sunshixuan@huidabiotech.com	China	3705	58

77814-07-4(ロフラミコイン)キーワード:

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• 77814-07-4
• 14,37-Dioxabicyclo[31.3.1]heptatriaconta-3,5,7,9,11-pentaen-13-one, 19,21,23,25,27,29,31,33,35-nonahydroxy-12,16-dimethyl-15-(1-methylethyl)-, (1R,3E,5E,7E,9E,11E,15S,16S,19S,21S,23S,25R,27R,29S,31R,33S,35S)- (9CI)
• Roflamycoin
• (2E,4E,6E,8E,10E,13R,15S,17S,19R,21S,23R,27S,29S,31S,34S,35S)-2-メチル-16-デメチル-12,13,32,33-テトラヒドロ-13,17-エポキシデルモスタチンA
• ロフラミコイン
• (1R,3Z,5Z,7Z,9Z,11Z,15S,16S,19S,21S,23S,27R,29S,31R,33S,35S)-19,21,23,25,27,29,31,33,35-ノナヒドロキシ-12,16-ジメチル-15-(プロパン-2-イル)-14,37-ジオキサビシクロ[31.3.1]ヘプタトリアコンタ-3,5,7,9,11-ペンタエン-13-オン