roflamycoin
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roflamycoin 속성
- 끓는 점
- 972.8±65.0 °C(Predicted)
- 밀도
- 1.154±0.06 g/cm3(Predicted)
- 산도 계수 (pKa)
- 12.67±0.70(Predicted)
안전
roflamycoin C화학적 특성, 용도, 생산
Synthesis
For Rychnovsky and co-worker’s synthesis of roflamycoin (45), the hemiketal-pyran linkage required differential substitution (Scheme 9) and demonstrated the power of the sequential double addition strategy.14 Treatment of bis-epoxide S,S-4 with a stoichiometric amount of (benzyloxy)methyllithium 38 and BF3?OEt2 in THF at –78 °C provided monoaddition adduct 39, which was then treated with the organolithium formed from transmetallation of 2,2-bis-(tributyltin)dithiane 40. This single-pot procedure afforded dithiane diol 41 in 56% overall yield. Subsequent acetonide formation and transmetallation provided a competent nucleophile for direct displacement of dibromide 42, which itself was derived from dichlorodiol R,R-3. The resulting bis-acetonide (43) was obtained in 60% overall yield and provided a rapid access to tris-acetonide 44, a key intermediate for the synthesis of the hemiketal-pyran moiety of 45. Similar sequential addition strategies have proven to be useful as well.
roflamycoin 준비 용품 및 원자재
원자재
준비 용품
roflamycoin 공급 업체
글로벌( 3)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903882 13626641628 |
jiangnan@huidabiotech.com | China | 3657 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 |
sunshixuan@huidabiotech.com | China | 3705 | 58 |