roflamycoin
- CAS No.
- 77814-07-4
- Chemical Name:
- roflamycoin
- Synonyms
- Roflamycoin;14,37-Dioxabicyclo[31.3.1]heptatriaconta-3,5,7,9,11-pentaen-13-one, 19,21,23,25,27,29,31,33,35-nonahydroxy-12,16-dimethyl-15-(1-methylethyl)-, (1R,3E,5E,7E,9E,11E,15S,16S,19S,21S,23S,25R,27R,29S,31R,33S,35S)- (9CI)
- CBNumber:
- CB88188494
- Molecular Formula:
- C40H66O12
- Molecular Weight:
- 738.94
- MDL Number:
- MOL File:
- 77814-07-4.mol
roflamycoin Chemical Properties,Uses,Production
Synthesis
For Rychnovsky and co-worker’s synthesis of roflamycoin (45), the
hemiketal-pyran linkage required differential substitution (Scheme 9) and
demonstrated the power of the sequential double addition strategy.14
Treatment of bis-epoxide S,S-4 with a stoichiometric amount of
(benzyloxy)methyllithium 38 and BF3?OEt2 in THF at –78 °C provided monoaddition adduct 39, which was then treated with the organolithium formed
from transmetallation of 2,2-bis-(tributyltin)dithiane 40. This single-pot
procedure afforded dithiane diol 41 in 56% overall yield. Subsequent
acetonide formation and transmetallation provided a competent nucleophile
for direct displacement of dibromide 42, which itself was derived from
dichlorodiol R,R-3. The resulting bis-acetonide (43) was obtained in 60%
overall yield and provided a rapid access to tris-acetonide 44, a key
intermediate for the synthesis of the hemiketal-pyran moiety of 45. Similar
sequential addition strategies have proven to be useful as well.
roflamycoin Preparation Products And Raw materials
Raw materials
Preparation Products
roflamycoin Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Zhejiang Huida Biotech Co., LTD | 0571-89903882 13626641628 | jiangnan@huidabiotech.com | China | 3656 | 58 |
Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 | sunshixuan@huidabiotech.com | China | 3705 | 58 |
Supplier | Advantage |
---|---|
BOC Sciences | 58 |
Zhejiang Huida Biotech Co., LTD | 58 |
Zhejiang Huida Biotech Co., LTD | 58 |