2-(4-ピリジル)-3-(2-プロポキシ-5-ブロモフェニル)-5-(4-クロロフェニル)-1H-ピロール 化学特性,用途語,生産方法
使用
L- is a potent (Kb = 25 nM), selective antagonist of glucagon.
生物活性
Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC 50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC 50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC 50 > 1 μ M). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC 50 = 41 nM), and in murine liver membranes. Orally active in vivo .
2-(4-ピリジル)-3-(2-プロポキシ-5-ブロモフェニル)-5-(4-クロロフェニル)-1H-ピロール 上流と下流の製品情報
原材料
準備製品