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2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

化学構造式
265312-55-8
CAS番号.
265312-55-8
化学名:
别名:
英語名:
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
英語别名:
RYUVIDINE;Cdk4 Inhibitor III;2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione;2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE;2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione;4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
CBNumber:
CB92453429
化学式:
C15H12N2O2S
分子量:
284.33
MOL File:
265312-55-8.mol
MSDS File:
SDS

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE 物理性質

沸点 :
463.8±45.0 °C(Predicted)
比重(密度) :
1.416±0.06 g/cm3(Predicted)
貯蔵温度 :
Store at +4°C
溶解性:
Soluble to 20 mM in DMSO and to 5 mM in ethanol
外見 :
黒紫無地
酸解離定数(Pka):
-1.63±0.20(Predicted)
色:
Brown to black

安全性情報

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC2609
Ryuvidine 		265312-55-8 10mg ￥73000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC2609
Ryuvidine 		265312-55-8 50mg ￥300000 2024-03-01 購入

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE 化学特性,用途語,生産方法

使用

Ryuvidine is an antifungal agent used against pathogenic fungi.

一般的な説明

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

生物活性

Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE 上流と下流の製品情報

原材料

準備製品

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE 生産企業

Global( 45)Suppliers
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265312-55-8()キーワード:

1-(2-メチル-1,3-チアゾール-4-イル)エタノン
  • 265312-55-8
  • 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
  • RYUVIDINE
  • Cdk4 Inhibitor III
  • 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione
  • 4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
  • 2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione
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