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ChemicalBook >> CAS DataBase List >>2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Structure
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE structure
CAS No.
265312-55-8
Chemical Name:
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
Synonyms
RYUVIDINE;Cdk4 Inhibitor III;2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione;2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE;2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione;4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
CBNumber:
CB92453429
Molecular Formula:
C15H12N2O2S
Molecular Weight:
284.33
MDL Number:
MFCD09971103
MOL File:
265312-55-8.mol
Last updated:2024-11-19 23:02:33
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2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Properties

Boiling point 463.8±45.0 °C(Predicted)
Density 1.416±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble to 20 mM in DMSO and to 5 mM in ethanol
form Black-purple solid
pka -1.63±0.20(Predicted)
color Brown to black

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 219478 Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem 265312-55-8 5mg $245 2024-03-01 Buy
Cayman Chemical 16614 Ryuvidine ≥95% 265312-55-8 1mg $33 2024-03-01 Buy
Cayman Chemical 16614 Ryuvidine ≥95% 265312-55-8 5mg $96 2024-03-01 Buy
Cayman Chemical 16614 Ryuvidine ≥95% 265312-55-8 10mg $160 2024-03-01 Buy
Cayman Chemical 16614 Ryuvidine ≥95% 265312-55-8 25mg $317 2024-03-01 Buy
Product number Packaging Price Buy
219478 5mg $245 Buy
16614 1mg $33 Buy
16614 5mg $96 Buy
16614 10mg $160 Buy
16614 25mg $317 Buy

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Chemical Properties,Uses,Production

Uses

Ryuvidine is an antifungal agent used against pathogenic fungi.

Definition

ChEBI: 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione is an aminotoluene.

General Description

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

Biological Activity

Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Preparation Products And Raw materials

Raw materials

Preparation Products

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Suppliers

Global( 46)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10311 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Tianjin shanhaijing medicine technology co., ltd 19129375004 15321929114 yangtzechem@163.com China 514 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4566 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Shanghai Changyan Chem & Tech Co., Ltd. 021-20242659 18930833303 Sales@changyanchem.cn China 5010 55
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Supplier Advantage
Shenzhen Nexconn Pharmatechs Ltd 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Tianjin shanhaijing medicine technology co., ltd 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Shanghai Lollane Biological Technology Co.,Ltd. 55
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Changyan Chem & Tech Co., Ltd. 55
DC Chemicals 58

View Lastest Price from 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ryuvidine pictures 2024-11-19 Ryuvidine
265312-55-8
 US $61.00-218.00 / mg 98.6% 10g TargetMol Chemicals Inc.
  • Ryuvidine pictures
  • Ryuvidine
    265312-55-8
  • US $61.00-218.00 / mg
  • 98.6%
  • TargetMol Chemicals Inc.

265312-55-8(2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE)Related Search:

1-(2-METHYL-1,3-THIAZOL-4-YL)ETHANONE 4,5-THIAZOLEDICARBOXALDEHYDE 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE RYUVIDINE Cdk4 Inhibitor III 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione 4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]- 2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione 265312-55-8 C15H13N2O2S