メトミダート

メトミダート 化学構造式
5377-20-8
CAS番号.
5377-20-8
化学名:
メトミダート
别名:
1-(1-フェニルエチル)-1H-イミダゾール-5-カルボン酸メチル;メトミダート;メチル 1-(1-フェニルエチル)-1H-イミダゾール-5-カルボキシラート
英語名:
metomidate
英語别名:
EM-01;Hypnodil;AquacalM;MethoxyMol;metomidate;Methomidate;MethoxyMol R-7315;Etomidate impurity B CRS;Etomidate Impurity 2 (Etomidate EP Impurity B);Methyl 3-(1-phenylethyl)imidazole-5-carboxylate
CBNumber:
CB9913785
化学式:
C13H14N2O2
分子量:
230.26
MOL File:
5377-20-8.mol

メトミダート 物理性質

沸点 :
372.26°C (rough estimate)
比重(密度) :
1.13
屈折率 :
1.6450 (estimate)
貯蔵温度 :
Refrigerator
溶解性:
クロロホルム、メタノール
酸解離定数(Pka):
4.15±0.23(Predicted)
色:
無色~淡黄色 濃い
InChI:
InChI=1S/C13H14N2O2/c1-10(11-6-4-3-5-7-11)15-9-14-8-12(15)13(16)17-2/h3-10H,1-2H3
InChIKey:
FHFZEKYDSVTYLL-UHFFFAOYSA-N
SMILES:
C1N(C(C2=CC=CC=C2)C)C(C(OC)=O)=CN=1

安全性情報

メトミダート 化学特性,用途語,生産方法

効能

催眠鎮静薬 (獣医薬)

化学的特性

Colourless Hazy Oil

使用

Metomidate is a the methyl ester analogue of Etomidate (E933300), with sedative and hypnotic properties. Metomidate is mainly used as an anesthetic for veterinary use on its own or in combination with Azaperone (A802200) and other sedatives.

作用機序

Metomidate reduces plasma cortisol and glucose concentrations and increases fish pigmentation, presumably because of increased production of melanocyte-stimulating hormone on the same primary protein as adrenocorticotropic hormone (ACTH). Imidazole anesthetics (e.g., metomidate and etomidate) interrupt cortisol synthesis in mammals by suppressing the enzyme 11-beta-hydroxylase, which is necessary for cortisol production.

メトミダート 上流と下流の製品情報

原材料

準備製品

5377-20-8(メトミダート)キーワード:


  • 5377-20-8
  • metomidate
  • 1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid methyl ester
  • Methomidate
  • 3-(1-phenylethyl)imidazole-4-carboxylic acid methyl ester
  • methyl 3-(1-phenylethyl)imidazole-4-carboxylate
  • Methyl 3-(1-phenylethyl)imidazole-5-carboxylate
  • 1-(α-Methylbenzyl)iMidazole-5-carboxylic Acid Methyl Ester
  • AquacalM
  • Hypnodil
  • MethoxyMol
  • MethoxyMol R-7315
  • Methyl 1-(α-Methylbenzyl)iMidazole-5-carboxylate
  • Methyl 1-[(1RS)-1-phenylethyl]-1H-imidazole-5-carboxylate
  • Etomidate impurity B CRS
  • 1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, methyl ester
  • Methyl 1-(1-Phenylethyl)-1H-Imidazole-5-Carboxylate
  • Etomidate Impurity 2 (Etomidate EP Impurity B)
  • EM-01
  • 1-(1-フェニルエチル)-1H-イミダゾール-5-カルボン酸メチル
  • メトミダート
  • メチル 1-(1-フェニルエチル)-1H-イミダゾール-5-カルボキシラート
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