Ibudilast
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Ibudilast 속성
- 녹는점
- 53-54°C
- 끓는 점
- 175°C/7.5mmHg(lit.)
- 밀도
- 1.09
- 굴절률
- 1.5500 (estimate)
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- DMSO: 28mg/mL, 용해성
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 1.22±0.30(Predicted)
- 색상
- 하얀색
- Merck
- 14,4879
- 안정성
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChI
- InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
- InChIKey
- ZJVFLBOZORBYFE-UHFFFAOYSA-N
- SMILES
- C(C1=C2N(N=C1C(C)C)C=CC=C2)(=O)C(C)C
- CAS 데이터베이스
- 50847-11-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38 | ||
| 안전지침서 | 26-36 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | UR0711200 | ||
| HS 번호 | 2933.99.8290 | ||
| 스토리지 클래스 | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| 독성 | LD50 i.v. in mice: 260 mg/kg (Irikura, 1973) |
Ibudilast C화학적 특성, 용도, 생산
개요
Ibudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.화학적 성질
White Solid용도
Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]생물학적 활성
Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.Ibudilast 준비 용품 및 원자재
원자재
준비 용품
Ibudilast 공급 업체
글로벌( 361)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Ruishang Science and Technology (Tianjin) Co., Ltd. | 15038222995 |
1951788154@qq.com | China | 60 | 58 |
| Shaanxi Zhong Zhi Biao Pin Pharmaceutical technology Co., LTD | 029-89239927 18009291534 |
18009291534@163.com | China | 376 | 58 |
| Jinan Hongwan Biotechnology Co., Ltd. | 58767175 13220585822 |
1256200339@qq.com | China | 62 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | |
sales@boylechem.com | China | 2915 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 |
market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 |
3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 |
sales@BioChemBest.com | China | 5996 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 |
Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 |
sales.bj@hwrkchemical.com | China | 9409 | 55 |