프로필파라벤

프로필파라벤
프로필파라벤 구조식 이미지
카스 번호:
94-13-3
한글명:
프로필파라벤
동의어(한글):
4-히드록시벤조산,프로필에스테르;P-히드록시벤조산,프로필에스테르;니파솔;베타시드P;보노몰드OP;솔브롤P;아세프토포름P;케모시드PK;테고세프트P;파라셉트;파세프톨;프레세르발P;프로타벤;프로필P-옥시벤조산;프로필아세프토포름;프로필케모세프트;프로필4-하이드록시벤조에이트;프로필P-히드록시벤조산;프로필파라벤;프로필파라세프트
상품명:
Propylparaben
동의어(영문):
Propyl parahydroxybenzoate;Parabens;PROPYL 4-HYDROXYBENZOATE;Nipazol;PROPYL P-HYDROXYBENZOATE;Nipasol;Nipasol M;4-HYDROXYBENZOIC ACID PROPYL ESTER;PROPYLPARABENE;Propyl parahydroxybenzoate CRS
CBNumber:
CB0176673
분자식:
C10H12O3
포뮬러 무게:
180.2
MOL 파일:
94-13-3.mol
MSDS 파일:
SDS

프로필파라벤 속성

녹는점
95-98 °C(lit.)
끓는 점
133°C
밀도
1.0630
증기압
0.67 hPa (122 °C)
굴절률
1.5050
FEMA
2951 | PROPYL P-HYDROXYBENZOATE
인화점
180°(356°F)
저장 조건
Sealed in dry,Room Temperature
용해도
에탄올: 용해성0.1M, 투명, 무색
산도 계수 (pKa)
pKa 8.4 (Uncertain)
물리적 상태
결정성 분말
Specific Gravity
0.789 (20/4℃)
색상
하얀색
수소이온지수(pH)
6-7 (H2O, 20°C) (saturated solution)
냄새
100.00%에서. 달콤한 스모키 번트 우디 산사나무
?? ??
향을 태우는 연기
수용성
12°C에서 <0.1g/100mL
Merck
14,7866
BRN
1103245
안정성
안정적인. 강한 산화제, 강한 염기와 호환되지 않습니다.
InChIKey
QELSKZZBTMNZEB-UHFFFAOYSA-N
LogP
2.8 at 20℃
CAS 데이터베이스
94-13-3(CAS DataBase Reference)
NIST
N-propyl-p-hydroxy-benzoate(94-13-3)
EPA
Propylparaben (94-13-3)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-24/25-36
WGK 독일 1
RTECS 번호 DH2800000
자연 발화 온도 >600 °C
TSCA Yes
HS 번호 29182930
유해 물질 데이터 94-13-3(Hazardous Substances Data)
독성 LD50 orally in Rabbit: > 5000 mg/kg
기존화학 물질 KE-20396
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P272 작업장 밖으로 오염된 의복을 반출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P333+P313 피부자극성 또는 홍반이 나타나면 의학적인 조치·조언를 구하시오.
P337+P313 눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
1
1 0

프로필파라벤 MSDS


4-Hydroxybenzoic acid propyl ester

프로필파라벤 C화학적 특성, 용도, 생산

화학적 성질

Propylparaben occurs as a white, crystalline, odorless, and tasteless powder.

용도

propylparaben is one of the most frequently used preservatives against bacteria and mold. It has a low sensitizing and low toxicity factor, is reputed to be very safe, and considered to be a noncomedogenic raw material.

정의

ChEBI: The benzoate ester that is the propyl ester of 4-hydroxybenzoic acid. Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. Also used as a food additive.

제조 방법

Produced by esterfying p-hydroxybenzoic acid with n-propanol, using an acid catalyst such as sulfuric acid and an excess of propanol. The materials are heated in a glass-lined reactor under reflux. The acid is then neutralized with caustic soda and the product is crystallized by cooling. The crystallized product is centrifuged, washed, dried under vacuum, milled and blended, all in corrosion-resistant equipment to avoid metallic contamination.

생산 방법

Propylparaben is prepared by the esterification of p-hydroxybenzoic acid with n-propanol.

일반 설명

Colorless crystals or white powder or chunky white solid. Melting point 95-98°C. Odorless or faint aromatic odor. Low toxicity, Tasteless (numbs the tongue). pH: 6.5-7.0 (slightly acidic) in solution.

공기와 물의 반응

Water soluble [Hawley].

반응 프로필

Maximum stability of Propylparaben occurs at a pH of 4 to 5. Incompatible with alkalis and iron salts. Also incompatible with strong oxidizing agents and strong acids .

화재위험

Flash point data for Propylparaben are not available; however, Propylparaben is probably combustible.

Pharmaceutical Applications

Propylparaben is widely used as an antimicrobial preservative in cosmetics, food products, and pharmaceutical formulations.
It may be used alone, in combination with other paraben esters, or with other antimicrobial agents. It is one of the most frequently used preservatives in cosmetics.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
Owing to the poor solubility of the parabens, the paraben salts, particularly the sodium salt, are frequently used in formulations. This may cause the pH of poorly buffered formulations to become more alkaline.
Propylparaben (0.02% w/v) together with methylparaben (0.18% w/v) has been used for the preservation of various parenteral pharmaceutical formulations.

색상 색인 번호

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Safety

Propylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations.
Propylparaben and methylparaben have been used as preservatives in injections and ophthalmic preparations; however, they are now generally regarded as being unsuitable for these types of formulations owing to the irritant potential of the parabens. Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. The WHO has set an estimated acceptable total daily intake for methyl, ethyl, and propyl parabens at up to 10 mg/kg body-weight.
LD50 (mouse, IP): 0.2 g/kg
LD50 (mouse, oral): 6.33 g/kg
LD50 (mouse, SC): 1.65 g/kg

저장

Aqueous propylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition.At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).

비 호환성

The antimicrobial activity of propylparaben is reduced considerably in the presence of nonionic surfactants as a result of micellization. Absorption of propylparaben by plastics has been reported, with the amount absorbed dependent upon the type of plastic and the vehicle. Magnesium aluminum silicate, magnesium trisilicate, yellow iron oxide, and ultramarine blue have also been reported to absorb propylparaben, thereby reducing preservative efficacy.
Propylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

Regulatory Status

Propylparaben and methylparaben are affirmed GRAS direct food substances in the USA at levels up to 0.1%. All esters except the benzyl ester are allowed for injection in Japan. In cosmetics, the EU and Brazil allow use of each paraben at 0.4%, but the total of all parabens may not exceed 0.8%. The upper limit in Japan is 1.0%.
Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM, IV, and SC injections; inhalations; ophthalmic preparations; oral capsules, solutions, suspensions, and tablets; otic, rectal, topical, and vaginal preparations).
Included in parenteral and nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

프로필파라벤 준비 용품 및 원자재

원자재

준비 용품


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