AZIMILIDE
|
|
AZIMILIDE 속성
- 끓는 점
- 594.9±60.0 °C(Predicted)
- 밀도
- 1.32
- 저장 조건
- 2-8°C
- 용해도
- <4.58mg/mL in DMSO
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 7.72±0.10(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 그림문자(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 신호 어: | Warning | ||||||||||||||
| 유해·위험 문구: |
|
||||||||||||||
| 예방조치문구: |
|
AZIMILIDE C화학적 특성, 용도, 생산
용도
Cardiac depressant (anti-arrhythmic).일반 설명
Azimilide, E-1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione, is a class III agent that significantlyblocks the delayed rectifier potassium current,Iks, including the Ikr component. Its ability to block multichannelsmay be caused by a lack of the methane sulfonamidegroup that is common to other class III agents, whichselectively block the Ikr potassium current. It is believedthat blocking both Ikr and Iks potassium currents yields consistentclass III antiarrhythmic effects at any heart rate.Clinical Use
Azimilde is another Class III antiarrhythmic agent structurally unrelated to any of the above agents. Azimilide is not available in the United States; it is only available in Europe. Following oral administration, the drug is completely absorbed, with no effect of food. Protein binding is 94%. It is metabolized in the liver to an active carboxylate metabolite, but its concentration in plasma is less than 5% of the parent compound. Thus, it is considered to be therapeutically inactive. Renal excretion is approximately 10%. Its elimination half-life is 3 to 4 days.효소 저해제
This class ΙΙΙ antiarrhythmic drug and ion channel blocker (FW = 457.95 g/mol; CAS 149908-53-2), also known by the code name NE-10064 and systematic name, 1-({(E)-[5-(4-chlorophenyl)furan-2-yl]methylidene} amino)-3-[4-(4-methylpiperazin-1-yl)butyl]-imidazolidine-2,4-dione, blocks both the slow-activating IKs and rapidly activating IKr components of the delayed rectifier potassium current, distinguishing its action from conventional potassium channel blockers such as sotalol and dofetilide,which block only IKr. Azimilide prolongs the cardiac refractory period in a dose-dependent manner, as manifested by increases in action potential duration, QTc interval, and effective refractory period.AZIMILIDE 준비 용품 및 원자재
원자재
2-Butyl-3-(3,5-Diiodo-4-hydroxy benzoyl) benzofuran
N-메틸피페라진
염화 n-부틸
염산
1-벤질리데네아미노히단토인
수소
5-(4-클로로페닐)-2-푸랄데히드
수소화나트륨
테트라메틸렌클로로브로마이드
Palladium hydroxide
아이오딘산나트륨
중탄산나트륨(중조)
준비 용품
AZIMILIDE 공급 업체
글로벌( 63)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32957 | 60 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15319487004 |
1015@dideu.com | China | 3210 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32161 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 22784 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9312 | 58 |
| TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38631 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 |
info@chemextension.com | China | 42056 | 58 |
| Shanghai Famo Biotech Co Ltd | +86-36680037 +86-18550473860 |
mayan@famobiotech.com;sales@famobiotech.com | China | 528 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131957 | 58 |