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2'-Deoxyguanosine monohydrate

2'-Deoxyguanosine monohydrate 구조식 이미지

카스 번호:: 312693-72-4

상품명:: 2'-Deoxyguanosine monohydrate

동의어(영문):: DG;DEOXYGUANOSINE-2';5′-Nucleotides &A-2'-DEOXYGUANOSINE;2'-DEOXY-D-GUANOSINE;Adenosine Impurity 16;GUANINE DESOXYRIBOSIDE;2'-DEOXYGUANOSINE USP/EP/BP;2'-Deoxyguanosine monohydrate;2'-Deoxyguanosine monohydrate

CBNumber:: CB0209021

분자식:: C10H15N5O5

포뮬러 무게:: 285.26

MOL 파일:: 312693-72-4.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 199

2'-Deoxyguanosine monohydrate 속성

녹는점: >300 °C (dec.)(lit.)

저장 조건: Keep in dark place,Sealed in dry,Room Temperature

용해도: NH₄OH 1 M: 50 mg/mL, 투명하거나 매우 희미하게 탁함, 노란색에서 갈색

물리적 상태: 가루

산도 계수 (pKa): pK1:2.5(+1) (25°C,μ=0.1)

색상: 흰색에서 황백색까지

BRN: 39814

InChI: InChI=1/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/s3

InChIKey: LZSCQUCOIRGCEJ-FPKZOZHISA-N

SMILES: OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)C[C@@H]1O |&1:2,4,17,r|

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn,T
위험 카페고리 넘버	22-25
안전지침서	45
WGK 독일	3
F 고인화성물질	10-23
TSCA	Yes
HS 번호	2934999090

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P312	삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P330	입을 씻어내시오.
P403	환기가 잘 되는 곳에 보관하시오.

NFPA 704

	0
2		0

2'-Deoxyguanosine monohydrate C화학적 특성, 용도, 생산

개요

2''-Deoxyguanosine is a purine nucleoside with diverse biological activities. It inhibits the clonogenic growth of HL-60 and K562 leukemia cells (IC₅₀s = 80 and 100 μM, respectively). 2''-Deoxyguanosine inhibits the growth of MOLT-4 T cells and MGL-8 B cells by 99.8 and 68.3%, respectively, when used at a concentration of 50 μM. It increases the number of binucleated cells, a marker of inhibited cytokinesis, in A. sativum meristems. 2''-Deoxyguanosine (>1 μM) also induces relaxation of precontracted isolated bovine lingual artery.

화학적 성질

White to Off-White Solid. Soluble in NH4OH 1 M: 50 mg/mL, clear to very faintly turbid.

정의

ChEBI: 2'-Deoxyguanosine monohydrate is a purine 2'-deoxyribonucleoside having guanine as the nucleobase. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside. It is functionally related to a guanosine.

주요 응용

2′-Deoxyguanosine monohydrate has been used as a nucleoside supplement:
to study its effect on mitochondrial DNA copy number in deoxyguanosine kinase (dguok) mutant zebrafish,
in tissue culture medium for deoxyribonucleotide triphosphate (dNTP) synthesis,
in RPMI (Roswell Park Memorial Institute)-1640 medium to eliminate the endogenous thymocytes.

Biological Functions

lu et al. found that 2'-Deoxyguanosine (2-dG) is a key immune signaling molecule in plant–microbe interactions and that Arabidopsis VENOSA4 (VEN4) is essential for plant immunity. 2-dG is the immunoreactive component in ZhiNengCong (ZNC). This compound induced classical immune responses, including ROS production, allose accumulation and MPKs phosphorylation, and upregulated the expression of plant immunity-associated genes. In addition, 2-dG-induced plant immunity requires salicylic acid (SA) receptor NPR1 (but not SA), ethylene (ET) signaling, pattern-recognition receptors/coreceptors (PRRs/coreceptors) and the ATP receptor P2K1[1]. VEN4 was involved in 2-dG biosynthesis and could convert dGTP to 2-dG.

2'-Deoxyguanosine monohydrate 준비 용품 및 원자재

원자재

준비 용품

2'-Deoxyguanosine monohydrate 공급 업체

글로벌( 199)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Beijing Ribio Biotech Co.,Ltd	010-62664360 +8613328773880	wucy@ribio.com.cn	China	117	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
SHANGHAI NOVRIBO BIOTECH	17821030819	June.Liu@Desano.com	China	73	58
Zhengzhou Chemprize Biotech Co., Ltd.	+86-86-0371-56768238 +8615981919713	sales@chemprize.com	China	297	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18151	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hangzhou Measure Life Technology Co., LTD	+8613343730176	2924244016@qq.com	China	83	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60

2'-Deoxyguanosine monohydrate 관련 검색:

N2-아이소부티릴-5'-O-(4,4'-디메톡시트리틸)-2'-데옥시구아노신 구아노신 1-METHYLGUANOSINE GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT DMT-dG(ib) Phosphoramidite 3'-GMP DISODIUM SALT ADENYLYL-(3'-5')-GUANOSINE N2-Isobutyryl-2'-deoxyguanosine 2'-Deoxyguanosine-5'-diphosphate trisodium salt 2’-deoxyguanosine5’-phosphat 2'-Deoxyguanosine 2’-deoxyguanosine5’-(tetrahydrogentriphosphate 2'-DEOXYGUANOSINE5'-MONOPHOSPHATE,DISODIUM SALT(DGMP·2NA) 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE N-ISOBUTYRYL-3'-O-BENZOYL-2'-DEOXYGUANOSINE 8-BROMOGUANOSINE 5'-MONOPHOSPHATE SODIUM SALT 8-MERCAPTOGUANOSINE 2',3',5-TRI-O-ACETYL-8-BROMOGUANOSINE