ChemicalBook >제품 카탈로그 >Boc-NH-PEG2-CH2COOH

Boc-NH-PEG2-CH2COOH

Boc-NH-PEG2-CH2COOH 구조식 이미지

카스 번호:: 108466-89-3

상품명:: Boc-NH-PEG2-CH2COOH

동의어(영문):: 2,2-DiMethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid;Boc-AEEA-OH;2-[2-[2-[(2-Methylpropan-2-yl)oxycarbonylaMino]ethoxy]ethoxy]acetic acid;Boc-O 2 Oc-OH;2-diMethyl-4-oxo-;BocNH-PEG2-CH2COOH;NHBoc-PEG2-CH2COOH;Boc-N-amido-PEG2-CH2CO2H;t-Boc-N-amido-PEG2-CH2CO2H;t-Boc-N-Amido-PEG2-CH2COOH

CBNumber:: CB02639228

분자식:: C11H21NO6

포뮬러 무게:: 263.29

MOL 파일:: 108466-89-3.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 166

Boc-NH-PEG2-CH2COOH 속성

끓는 점: 425.7±30.0 °C(Predicted)

밀도: 1.145±0.06 g/cm3(Predicted)

저장 조건: -20°C

산도 계수 (pKa): 3.40±0.10(Predicted)

물리적 상태: 액체

색상: 노란색

InChI: InChI=1S/C11H21NO6/c1-11(2,3)18-10(15)12-4-5-16-6-7-17-8-9(13)14/h4-8H2,1-3H3,(H,12,15)(H,13,14)

InChIKey: OMBVJVWVXRNDSL-UHFFFAOYSA-N

SMILES: C(O)(=O)COCCOCCNC(=O)OC(C)(C)C

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

HS 번호	2918999090

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

Boc-NH-PEG2-CH2COOH C화학적 특성, 용도, 생산

용도

t-Boc-N-amido-PEG₂-CH₂CO₂H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG₂-CH₂CO₂H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Synthesis

To a stirred solution of 2-(2-(2-Aminoethoxy)ethoxy)acetic acid (5.0 g, 30.6 mmol) in 1,4-Dioxane (50 mL), Sodium carbonate (8.12 g, 76.5 mmol, dissolved in 10 mL water) and (Boc)2O (9.98 mL, 45.7 mmol) were added and stirred at room temperature for 12 h. The progress of the reaction was monitored by TLC. The reaction mass was partitioned between diethyl ether and water. Then, the aqueous layer was made acidic (pH = 3) by 3N HC1 solution and was extracted with DCM (2 x 200 mL). The organic layer was washed with water, and brine, dried over Na2504 and evaporated under reduced pressure to yield 50 g of pure Boc-NH-PEG2-CH2COOH (Yield:62.1 per cent).

Boc-NH-PEG2-CH2COOH 준비 용품 및 원자재

원자재

3,6,11-Trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo-, phenylmethyl ester 2-(2-(2-아미노에톡시)에톡시)아세트산염산염 2-(2-BOC-아미노에톡시)에탄올 브로모아세트산 BOC-8-아미노-3,6-디옥사옥탄산DCHA 2-(2-아미노에톡시)에탄올 디 -Tert- 부틸 디 카보네이트 2-(2-(2-아미노에톡시)에톡시)아세트산 에틸브로모아세트산 소듐 아이오도아세테이트

준비 용품

Boc-NH-PEG2-CH2COOH 공급 업체

글로벌( 166)공급 업체

공급자	전화	이메일	국가	제품 수	이점
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD	+8618291886785	olivia.wang@pushanshiye.com	China	164	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29798	60
9i LLC	+18039569191	MWan@NiNeiLab.com	United States	418	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21667	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29888	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	19447	58
Chengdu Pukang Biotechnology Co., Ltd	028-82550498	export@pu-kang.com	CHINA	210	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
Chengdu Feibo Pharm Technology Co., Ltd	15982321820	abby@arkpharm.com	CHINA	3279	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39916	58

Boc-NH-PEG2-CH2COOH 관련 검색:

N-Boc-PEG6-alcohol N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester O-[2-(Boc-amino)ethyl]-Oμ-(2-carboxyethyl)polyethylene glycol 3,000 Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID BOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID Z-8-aMino-3,6-dioxaoctanoic acid t-Boc-N-amido-PEG5-acid Boc-9-AMino-4,7-Dioxanonanoic acid 5,8,11,14-Tetraoxa-2-azahexadecanoic acid,16-amino-,1,1-dimethyl ester O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL) t-Boc-N-amido-PEG2-acid 2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID t-Boc-N-amido-PEG1-acid