아세트초산에틸
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아세트초산에틸 속성
- 녹는점
- −43 °C(lit.)
- 끓는 점
- 181 °C(lit.)
- 밀도
- 1.029 g/mL at 20 °C(lit.)
- 증기 밀도
- 4.48 (vs air)
- 증기압
- 1 mm Hg ( 28.5 °C)
- 굴절률
- n
20/D 1.419
- 인화점
- 185 °F
- 저장 조건
- Store below +30°C.
- 용해도
- 116g/L(20°C)
- 산도 계수 (pKa)
- 11(at 25℃)
- 물리적 상태
- 액체
- 색상
- APHA: ≤15
- Specific Gravity
- 1.027~1.035 (20/4℃)
- 상대극성
- 0.577
- 수소이온지수(pH)
- 4.0 (110g/l, H2O, 20℃)
- 냄새
- 기분 좋은 과일 맛.
- ?? ??
- 과일 같은
- 폭발한계
- 1.0-54%(V)
- 수용성
- 116g/L(20℃)
- JECFA Number
- 595
- Merck
- 14,3758
- BRN
- 385838
- Dielectric constant
- 15.0(Ambient)
- 안정성
- 안정적인. 산, 염기, 산화제, 환원제, 알칼리 금속과 호환되지 않습니다. 타기 쉬운.
- InChIKey
- XYIBRDXRRQCHLP-UHFFFAOYSA-N
- LogP
- 0.8 at 20℃
- CAS 데이터베이스
- 141-97-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36 | ||
안전지침서 | 26-24/25 | ||
유엔번호(UN No.) | UN 1993 | ||
WGK 독일 | 1 | ||
RTECS 번호 | AK5250000 | ||
자연 발화 온도 | 580 °F | ||
TSCA | Yes | ||
위험 등급 | 3.2 | ||
포장분류 | III | ||
HS 번호 | 29183000 | ||
유해 물질 데이터 | 141-97-9(Hazardous Substances Data) | ||
독성 | LD50 orally in rats: 3.98 g/kg (Smyth) | ||
기존화학 물질 | KE-27567 |
아세트초산에틸 C화학적 특성, 용도, 생산
물성
쾌활한 과일 냄새가 나는 무색 투명 액체. 그것은 에탄올, 에틸 에테르, 프로필렌 글리콜 및 에틸 아세테이트에 쉽게 용해되고 1:12로 물에 용해된다. 끓는 점 : 181 ° C, 융점 : -45 ° C (enol : -80 ° C, 케톤 : -39 ° C), 인화점 : 84.5 ° C.용도
주로 의학, 염료, 살충제 등에 사용됩니다. 또한 식품 첨가물 및 향료 및 향수에 사용할 수 있습니다.순도시험
(1) 비중 : 이 품목의 비중은 1.022~1.027이어야 한다.
(2) 굴절률 : 이 품목의 굴절률 은 1.418~1.421이어야 한다.
(3) 용상 : 이 품목 1mL를 30% 에탄올 3mL에 녹일 때, 그 액은 징명하여야 한다.
(4) 유리산 : 이 품목 15mL에 새로 끓여 식힌 물 15mL를 넣어 2분간 흔들어 섞어 정치한 후 그 물층 10mL를 취해 페놀프탈레인시액 2방울 및 0.1N 수산화칼륨용액 3.4mL를 넣을 때, 홍색을 나타낸다.
확인시험
(1) 이 품목 1mL를 에탄올 3mL에 녹여 염화제이철시액 1방울을 넣으면 적자색을 나타낸다.
(2) 이 품목 0.5mL에 10% 알콜성수산화칼륨시액 5mL를 넣어 온탕 중에서 5분간 가열하고 식힌 다음 이에 물 10mL 및 묽은염산 2mL를 넣은 액은 확인시험법 중 초산염 (다)의 반응을 나타낸다.
정량법
이 품목 약 0.8g을 정밀히 달아 향료시험법 중 알데히드류 및 케톤류함량측정법의 히드록실아민법 중 제2법에 따라 시험한다. 다만, 방치시간은 15분간으로 한다.
0.5N 염산 1mL = 65.07mg C6H10O3
개요
The organic compound ethyl acetoacetate (EAA) is the ethyl ester of acetoacetic acid. It is mainly used as a chemical intermediate in the production of a wide variety of compounds, such as amino acids, analgesics, antibiotics, antimalarial agents, antipyrine and amino pyrine, and vitamin B1; as well as the manufacture of dyes, inks, lacquers, perfumes, plastics, and yellow paint pigments. Alone, it is used as a flavoring for food.화학적 성질
Ethyl 3-Oxobutanoate is a colorless liquid with a fruity, ethereal, sweet odor reminiscent of green apples. It is used to create fresh, fruity top notes in feminine fine fragrances. Ethyl acetoacetate occurs in flavors of natural materials such as coffee, strawberries, and yellow passion fruits.출처
Naturally occurring in strawberry, coffee, sherry, passion fruit juice (yellow), babaco fruit (Carica pentagona Heilborn) and bread.용도
Ethyl acetoacetate (EAA) is used as starting material for the syntheses of alpha-substituted acetoacetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives as well as intermediate for vitamins and pharmaceuticals. Product Data Sheet정의
This compound is a tautomer at room temperature consisting of about 93% keto form and 7% enol form.제조 방법
Ethyl acetoacetate is produced industrially by treatment of diketene with ethanol.The preparation of ethyl acetoacetate is a classic laboratory procedure . It is prepared via the Claisen condensation of ethyl acetate. Two moles of ethyl acetate condense to form one mole each of ethyl acetoacetate and ethanol.
생산 방법
Ethyl acetoacetate is manufactured through a reaction of high-purity ethyl acetate with sodium, followed by neutralization with sulfuric acid.일반 설명
A colorless liquid with a fruity odor. Flash point 185°F. Boiling point 365°F. May cause adverse health effects if ingested or inhaled. May irritate to skin, eyes and mucous membranes. Used in organic synthesis and in lacquers and paints.공기와 물의 반응
Flammable.반응 프로필
Ethyl acetoacetate, a beta-keto ester, is more reactive than many esters. Undergoes an exothermic cleavage reaction in the presence of concentrated base. Reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Mixing with 2,2,2-tris(bromomethyl)ethanol and zinc led to an explosion [US Patent 3 578 619, Crotonaldehyde may rapidly polymerize with Ethyl acetoacetate (Soriano, D.S. et al. 1988. Journal of Chemical Education 65:637.).1971].위험도
Toxic by ingestion and inhalation; irritant to skin and eyes.건강위험
Liquid may cause mild irritation of eyes.화학 반응
Ethyl acetoacetate is subject to Keto - enol tautomerism. Ethyl acetoacetate is often used in the acetoacetic ester synthesis similar to diethyl malonate in the malonic ester synthesis or the Knoevenagel condensation. The protons alpha to carbonyl groups are acidic, and the resulting carbanion can undergo nucleophilic substitution. A subsequent thermal decarboxylation is also possible.Similar to the behavior of acetylacetone, the enolate of ethyl acetoacetate can also serve as a bidentate ligand. For example, it forms purple coordination complexes with iron (III) salts :Ethyl acetoacetate can also be reduced to ethyl 3-hydroxy butyrate.
Safety Profile
eye irritant. Combustible liquid when exposed to heat or flame; can react with oxidzing materials. Explosive reaction when heated with Zn + tribromoneopentyl alcohol or 2,2,2 tris(bromomethy1)ethanol. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.Purification Methods
Shake the ester with small amounts of saturated aqueous NaHCO3 (until no further effervescence), then with water. Dry it with MgSO4 or CaCl2 and distil it under reduced pressure. [Beilstein 3 IV 1528.]아세트초산에틸 준비 용품 및 원자재
원자재
준비 용품
3-CHLORO-4-METHYL-7-HYDROXYCOUNMARIN
Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate
BISPYRAZOLONE
4-CHLORO-2,6-DIMETHYL-NICOTINIC ACID
에틸2,4-디메틸퀴놀린-3-카르복실레이트
Disperse Yellow H-4GL
에틸2-아세틸-3-옥소-헥사노에이트
1-(6-CHLORO-2-HYDROXY-4-PHENYL-QUINOLIN-3-YL)-ETHANONE
Ethyl 3-hydroxybutyrate
5-메틸-1-페닐-1H-피라졸-4-카르복실산
PHENOXYACETIC ACID
5,7-Dihydroxy-4-methylcoumarin
4-HYDROXY-2-METHYLQUINOLINE
ETHYL 4-CHLORO-2,6-DIMETHYLPYRIDINE-3-CARBOXYLATE
7-(아세틸옥시)-4-메틸-2-벤조파이론
3-ETHOXYCARBONYL-5,6-DIHYDRO-2-METHYL-4H-PYRAN
N-Phenylglycine potassium salt
TIADINIL
에틸5-메틸-1-페닐-1H-피라졸-4-카르복실레이트
1-브로모-5-헥사논
Pentoxifylline
6-TERT-BUTYL-4-METHYLCOUMARIN
쿠마린 4
에틸2-(하이드록시이미노)-3-옥소부타노에이트
Cloricromene
2,4-DIMETHYLQUINOLINE-3-CARBOXYLIC ACID
Acetoacetic Acid
에틸3-아닐리노부트-2-에노에이트
(5-METHYL-1-PHENYL-1H-PYRAZOL-4-YL)메탄올
크리신
4,7-디메틸쿠마린
4- 에틸 -3- 메틸 -1,2- 디하이드로피롤 -5- 온
4-Chloro-6-methyl-2-(methylthio)pyrimidine
2-Amino-6-methyl-4-pyrimidinol
4-메틸쿠마린
1,3-디메틸-5-히드록시피라졸
6-Methyl-2-(methylthio)pyrimidin-4-ol
7,8-DIHYDROXY-4-METHYLCOUMARIN
3-메틸-5-페닐-4-이속사졸탄산
에틸2-[2-(디에틸아미노)에틸]아세토아세테이트
아세트초산에틸 공급 업체
글로벌( 880)공급 업체
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Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-17333973358 |
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Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
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