염화벤잘코늄
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염화벤잘코늄 속성
- 끓는 점
- >100°C/760mmHg
- 밀도
- 0.98
- 저장 조건
- Store below +30°C.
- 용해도
- 물과 에탄올(96%)에 매우 잘 녹습니다. 산성 수용액을 흔들면 거품이 많이 납니다.
- 물리적 상태
- 점성 용액
- Specific Gravity
- 0.98
- 색상
- 투명하거나 흰색에서 노란색까지, 노란색-흰색 조각이 포함될 수 있음
- 안정성
- 안정적인. 강한 산화제, 습기와 호환되지 않습니다. 흡습성.
- InChI
- InChI=1S/C10H16N.ClH/c1-11(2,3)9-10-7-5-4-6-8-10;/h4-8H,9H2,1-3H3;1H/q+1;/p-1
- InChIKey
- KXHPPCXNWTUNSB-UHFFFAOYSA-M
- SMILES
- C1C=C(C[N+](C)(C)C)C=CC=1.[Cl-]
- LogP
- 1.692 (est)
- CAS 데이터베이스
- 8001-54-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | C,N | ||
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위험 카페고리 넘버 | 21/22-34-50 | ||
안전지침서 | 36/37/39-45-61 | ||
유엔번호(UN No.) | UN 3261 8/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | BO3151000 | ||
F 고인화성물질 | 3-9 | ||
HS 번호 | 34021200 | ||
유해 물질 데이터 | 8001-54-5(Hazardous Substances Data) | ||
독성 | LD50 orally in rats: 400 mg/kg (Cummins, Kimura) | ||
기존화학 물질 | KE-00790 | ||
유해화학물질 필터링 | 97-1-200 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 염화 N-알킬디메틸벤질암모늄 및 이를 1% 이상 함유한 혼합물 |
그림문자(GHS): |
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신호 어: | Danger | ||||||||||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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염화벤잘코늄 C화학적 특성, 용도, 생산
개요
Benzalkonium chloride is a quaternary ammonium mixture of alkyl, dimethyl and benzyl ammonium chlorides.It is an irritant rather than a sensitizer, but may cause contact dermatitis in nursing and medical personnel. An unusual case was reported in a farm worker who used a detergent containing benzalkonium chloride to clean the piggery.화학적 성질
Benzalkonium chloride occurs as a white or yellowish-white amorphous powder, a thick gel, or gelatinous flakes. It is hygroscopic, soapy to the touch, and has a mild aromatic odor and very bitter taste.용도
benzalkonium chloride is a preservative with anti-microbial and deodorant properties. It can also be used as a surfactant. With continuous use, it may cause occasional allergic reactions.정의
ChEBI: A class of quaternary ammonium chloride salts in which the nitrogen is substituted by a benzyl group, two methyl groups and an even-numbered alkyl chain.생산 방법
Benzalkonium chloride is formed by the reaction of a solution of Nalkyl- N-methylbenzamine with methyl chloride in an organic solvent suitable for precipitating the quaternary compound as it is formed.위험도
Highly toxic; poison.Pharmaceutical Applications
Benzalkonium chloride is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative in applications similar to other cationic surfactants, such as cetrimide. In ophthalmic preparations, benzalkonium chloride is one of the most widely used preservatives,at a concentration of 0.01–0.02% w/v. Often it is used in combination with other preservatives or excipients, particularly 0.1% w/v disodium edetate, to enhance its antimicrobial activity against strains of Pseudomonas.In nasal, and otic formulations a concentration of 0.002–0.02% w/v is used, sometimes in combination with 0.002–0.005% w/v thimerosal. Benzalkonium chloride 0.01% w/v is also employed as a preservative in small-volume parenteral products. Benzalkonium chloride was also shown to enhance the topical penetration of lorazepam.
Benzalkonium chloride is additionally used as a preservative in cosmetics.
농업용
Biocide, Algaecide, Fungicide: Used as an algaecide to control slime mold, algae, fish pathogens, and mollusks in ponds, canals and bodies of water. Also widely used in deodorants, detergents, sanitizers and germicides for applications in food plants, laundries, and operating rooms. Not listed for use in EU countries . Registered for use in the U.S. but not California.상품명
AMMONYX®; ARQUAD DMMCB-75®; BARQUAT® MB-50; BARQUAT® MB-80; BAYCLEAN®; BIO-QUAT 50-24®; CATAMINE® AB; CONSAN®; DRAPOLENE®; GARDIQUAT®-1450; HYAMINE®-3500; INTEXAN® LB-50; KATAMINE® AB; NEO GERM-I-TOL®; ONYX BTC; OSVAN; RODALON®; SENTINEL®; TRITON® K-60; VIKROL® RQ색상 색인 번호
This quaternary ammonium cationic surfactant is a mixture of alkyl, dimethyl, and benzyl ammonium chlorides (-R). It is an irritant rather than a sensitizer, but may cause allergic contact dermatitis from creams, detergents/antiseptics, ophthalmic preparations, and in nursing, veterinary, dental, and medical personnel. Its presence was observed in plaster of Paris.Clinical Use
Alkylbenzyldimethylammonium chloride (Zephiran) is a mixtureof alkylbenzyldimethylammonium chlorides of the generalformula [C6H5CH2N(CH3)2R] Cl , where R represents amixture of alkyl chains beginning with C8H17 and extendingto higher homologues with C12H25, C14H29, and C16H33. The higher–molecular-weight homologues compose the majorfractions. Although variations in the physical and antimicrobialproperties exist between individual members of the mixture,they are of little importance in the chemistry of the overallproduct. Benzalkonium chloride occurs as a white gel thatis soluble in water, alcohol, and organic solvents. Aqueous solutionsare colorless, slightly alkaline, and very foamy.Benzalkonium chloride is a detergent, an emulsifier, anda wetting agent. It is used as an antiseptic for skin and mucousmembranes in concentrations of 1:750 to 1:20,000. Forirrigation, 1:20,000 to 1:40,000 concentrations are used. Forstorage of surgical instruments, 1:750 to 1:5,000 concentrationsare used, with 0.5% NaNO3 added as a preservative.
부작용
Clinically, benzalkonium chloride may cause eye irritation and is known to discolour soft contact lenses. Benzalkonium chloride in eye drops has also been reported to cause punctate keratopathy and/or toxic ulcerative keratopathy, especially in frequent or prolonged use or in conditions where the cornea is compromised.저장
Benzalkonium chloride is hygroscopic and may be affected by light, air, and metals.Solutions are stable over a wide pH and temperature range and may be sterilized by autoclaving without loss of effectiveness. Solutions may be stored for prolonged periods at room temperature. Dilute solutions stored in polyvinyl chloride or polyurethane foam containers may lose antimicrobial activity.
The bulk material should be stored in an airtight container, protected from light and contact with metals, in a cool, dry place.
비 호환성
Incompatible with aluminum, anionic surfactants, citrates, cotton, fluorescein, hydrogen peroxide, hypromellose,iodides, kaolin, lanolin, nitrates, nonionic surfactants in high concentration, permanganates, protein, salicylates, silver salts, soaps, sulfonamides, tartrates, zinc oxide, zinc sulfate, some rubber mixes, and some plastic mixes.Benzalkonium chloride has been shown to be adsorbed to various filtering membranes, especially those that are hydrophobic or anionic.
Regulatory Status
Included in the FDA Inactive Ingredients Database (inhalations, IM injections, nasal, ophthalmic, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. It is also included in the Canadian List of Acceptable Non-medicinal Ingredients.염화벤잘코늄 준비 용품 및 원자재
원자재
준비 용품
염화벤잘코늄 공급 업체
글로벌( 454)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Anhui Royal Chemical Co., Ltd. | +86-25-86655873 +8613962173137 |
marketing@royal-chem.com | China | 189 | 55 |
Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd | 510-85010237 |
overseamarketing@alphahi-tech.com | CHINA | 41 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20294 | 58 |
Hebei Fengmu Trading Co., Ltd. | +8613393234347 |
Lyla@fengmuchem.com | China | 2982 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +8613288715578 |
angelia@hbmojin.com | China | 830 | 58 |
Hebei Yime New Material Technology Co., Ltd. | +86-66697723 +86-17703311139 |
admin@china-yime.com | China | 563 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5989 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2989 | 58 |
Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 |
kyra@quanjinci.com | China | 1534 | 58 |
염화벤잘코늄 관련 검색:
염화 벤제토늄 벤질 C8-18 알킬다이메틸암모늄 클로라이드 염화벤잘코늄 염화 벤질(C12-C16)알킬다이메틸암모늄 C.I. 색소 황색 13 염화 (C12-C18)알킬벤질다이메틸 암모늄 코코알킬 다이메틸벤질암모늄 클로라이드
Benzyldodecyldimethylammonium bromide
RARECHEM AL BO 1227
AKOS PAO-1227
AKOS BC-1227
QUATERNIUM-18/BENZALKONIUM BENTONITE
BENZALKONIUM CHLORIDE 80% (BKC80%)
geramine 1227
BENZALKONIUM CHLORIDE (14529)
RARECHEM AN KB 1227
RARECHEM AN KC 1227
BENZALKONIUM CHLORIDE MM(CRM STANDARD)