염화 벤제토늄
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염화 벤제토늄 속성
- 녹는점
- 162-164 °C (lit.)
- 끓는 점
- 162℃[at 101 325 Pa]
- 밀도
- 0.998 g/mL at 20 °C
- 증기압
- < 0.001 hPa @ 2°C
- 굴절률
- 1.5650 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- H2O: 0.1 M at 20 °C, 투명, 무색
- 물리적 상태
- 액체
- 색상
- 하얀색
- 수소이온지수(pH)
- 5.5-7.5 (25℃, 0.1M in H2O)
- 냄새
- 냄새 없는
- pH 범위
- 5.5 - 7.5
- 수용성
- 18°C에서 1~5g/100mL
- 감도
- Hygroscopic
- Merck
- 14,1074
- BRN
- 3898548
- 안정성
- 안정성 안정적이지만 흡습성이 있습니다. 강한 산화제, 비누, 음이온 세제, 질산염, 산과 호환되지 않습니다. 빛에 민감합니다.
- LogP
- 1.08 at 20℃
- CAS 데이터베이스
- 121-54-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,N,C | ||
---|---|---|---|
위험 카페고리 넘버 | 22-37/38-41-36-36/37/38-20/21/22-50/53-34-52/53 | ||
안전지침서 | 26-36/39-24/25-36/37/39-61-45 | ||
유엔번호(UN No.) | UN1759 | ||
WGK 독일 | 2 | ||
RTECS 번호 | BO7175000 | ||
F 고인화성물질 | 8 | ||
TSCA | Yes | ||
위험 등급 | 8 | ||
포장분류 | III | ||
HS 번호 | 29239000 | ||
유해 물질 데이터 | 121-54-0(Hazardous Substances Data) | ||
독성 | LD50 i.v. in mice: 29.5 mg/kg (Weiss) | ||
기존화학 물질 | KE-11871 |
염화 벤제토늄 C화학적 특성, 용도, 생산
화학적 성질
Benzethonium chloride occurs as a white crystalline material with a mild odor and very bitter taste.용도
Benzethonium Chloride USP is used as germicide for pharmaceutical and cosmetic products. (USP grade of Hyamine(R) 1622 crystals).정의
ChEBI: A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it i active against a broad spectrum of bacteria, fungi, moulds and viruses.생산 방법
p-Diisobutylphenol is condensed in the presence of a basic catalyst with β,β'-dichlorodiethyl ether to yield 2-[2-[4-(1,1,3,3-tetramethylbutyl) phenoxy]ethoxy]ethyl chloride. Alkaline dimethylamination then produces the corresponding tertiary amine which, after purification by distillation, is dissolved in a suitable organic solvent and treated with benzyl chloride to precipitate benzethonium chloride.일반 설명
Odorless white crystals or powder with a very bitter taste. A 1% solution in water is slightly alkaline to litmus.공기와 물의 반응
Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble.반응 프로필
Benzethonium chloride is incompatible with strong oxidizing agents Incompatible with soap and anionic detergents. Can react with nitrates. Sensitive to light. Acids cause Benzethonium chloride to precipitate from aqueous solutions of >2% concentration. Stable for two weeks at temperatures up to 140 F, .위험도
An oral poison.화재위험
Flash point data for Benzethonium chloride are not available. Benzethonium chloride is probably combustible.Pharmaceutical Applications
Benzethonium chloride is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative. Typically, it is used for this purpose in injections, ophthalmic and otic preparations at concentrations 0.01–0.02% w/v. Benzethonium chloride may also be used as a wetting and solubilizing agent, and as a topical disinfectant.In cosmetics such as deodorants, benzethonium chloride may be used as an antimicrobial preservative in concentrations up to 0.5% w/v.
The physical properties and applications of benzethonium chloride are similar to those of other cationic surfactants such as cetrimide.
Safety Profile
Poison by ingestion,subcutaneous, intraperitoneal, and intravenous routes. Asevere eye irritant. Questionable carcinogen withexperimental neoplastigenic data. Mutation data reported.When heated to decomposition it emits very toxic fumesof Cl -Safety
Benzethonium chloride is readily absorbed and is generally regarded as a toxic substance when administered orally. Ingestion may cause vomiting, collapse, convulsions, and coma. The probable lethal human oral dose is estimated to be 50–500 mg/kg bodyweight.The topical use of solutions containing greater than 5% w/v benzethonium chloride can cause irritation although benzethonium chloride is not regarded as a sensitizer. The use of 0.5% w/v benzethonium chloride in cosmetics is associated with few adverse effects. A maximum concentration of 0.02% w/v benzethonium chloride is recommended for use in cosmetics used in the eye area and this is also the maximum concentration generally used in pharmaceutical formulations such as injections and ophthalmic preparations.
See also Benzalkonium Chloride.
LD50 (mouse, IP): 15.5 mg/kg
LD50 (mouse, IV): 30 mg/kg
LD50 (mouse, oral): 338 mg/kg
LD50 (rat, IP): 16.5 mg/kg
LD50 (rat, IV): 19 mg/kg
LD50 (rat, oral): 368 mg/kg
LD50 (rat, SC): 119 mg/kg
저장
Benzethonium chloride is stable. Aqueous solutions may be sterilized by autoclaving.The bulk material should be stored in an airtight container protected from light, in a cool, dry place.
Purification Methods
Crystallise it from boiling acetone after filtering or from CHCl3/pet ether. The precipitate is filtered off, washed with diethyl ether and dried for 24hours in a vacuum desiccator. It is a cationic antiseptic surfactant which forms crystals also from a 1:9 MeOH/Et2O mixture. It foams in water. [Beilstein 12 IV 2187.]비 호환성
Benzethonium chloride is incompatible with soaps and other anionic surfactants and may be precipitated from solutions greater than 2% w/v concentration by the addition of mineral acids and some salt solutions.Regulatory Status
Included in the FDA Inactive Ingredients Database (IM and IV injections; nasal, ophthalmic and otic preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients.염화 벤제토늄 준비 용품 및 원자재
원자재
준비 용품
염화 벤제토늄 공급 업체
글로벌( 652)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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CD Chemical Group Limited | +8615986615575 |
info@codchem.com | China | 20356 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49739 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5867 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2989 | 58 |
Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 |
kyra@quanjinci.com | China | 1534 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 973 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |