칼콘
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칼콘 속성
- 녹는점
- 55-59 °C
- 끓는 점
- 208 °C25 mm Hg(lit.)
- 밀도
- d462 1.0712
- 굴절률
- nD62 1.6458
- 인화점
- >230 °F
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 디옥산: 용해성1g/10mL, 투명, 무색
- 물리적 상태
- 과립분말
- 색상
- 노란색
- Merck
- 14,2037
- BRN
- 1210466
- LogP
- 3.080
- CAS 데이터베이스
- 94-41-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37 | ||
안전지침서 | 22-36/37/39-45 | ||
WGK 독일 | 3 | ||
RTECS 번호 | UD5576750 | ||
HS 번호 | 29143900 |
칼콘 C화학적 특성, 용도, 생산
개요
Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids.They show antibacterial, antifungal, antitumor and anti-inflammatory properties. They are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities. Chalcones are also intermediates in the Auwers synthesis of flavones.화학적 성질
light yellow powder용도
Chalcone is used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines. It also inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase.정의
ChEBI: A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group.제조 방법
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.Chalcones can be prepared by an aldol condensation between a benzaldehyde and an acetophenone in the presence of sodium hydroxide as a catalyst.
This reaction has been found to work without any solvent at all - a solid-state reaction. The reaction between substituted benzaldehydes and acetophenones has been used to demonstrate green chemistry in undergraduate chemistry education.In a study investigating green chemistry synthesis, chalcones were also synthesized from the same starting materials in high temperature water (200 to 350 °C).
생물학적 활성
1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.Safety Profile
Poison by intravenous route. See also KETONES. When heated to decomposition it emits acrid smoke and irritating fumes.Purification Methods
Crystallise it from EtOH by warming to 50o (about 5mL/g), iso-octane, or toluene/pet ether, or recrystallise it from MeOH, and then twice from hexane. SKIN IRRITANT. [Beilstein 7 IV 1658.]칼콘 준비 용품 및 원자재
원자재
아세톤
트랜스칼콘
1-Butanone, 3-hydroxy-3-Methyl-1-phenyl-
3-Benzenesulfonyl-1,3-diphenyl-propan-1-one
아이오도벤젠
아세토페논
에티일벤젠
1-페닐-2-프로펜-1-온
브로모벤젠
1,3-DIPHENYL-2-프로핀-1-OL
염화벤조일
벤질 알코올
벤즈알데하이드
준비 용품
칼콘 공급 업체
글로벌( 221)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12495 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20291 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
zhangjiagang vinsce bio-pharm. limited. | 86-512-58389969 |
sales1@swellxin.com | CHINA | 111 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 905 | 58 |
칼콘 관련 검색:
스티렌 모노머
2',4,4'-TRIHYDROXY-3-METHOXY CHALCONE
2',3,4,4'-Tetrahydroxy-trans-chalcone
trans-Chalcone
4-Chloro-4'-methoxy-trans-chalcone
(E)-2',4-Dihydroxy-4'-(β-D-glucopyranosyloxy)chalcone
(E)-4'-(Dimethylamino)chalcone
4-Diethylamino-α-methyl-3',4',5'-trimethoxy-trans-chalcone
4-Amino-β-methyl-3',4',5'-trimethoxy-trans-chalcone
α-Methyl-2',3',4'-trimethoxy-trans-chalcone
4-Acetylamino-3',4',5'-trimethoxy-trans-chalcone
4-Nitro-cis-chalcone
2'-HYDROXY-6'-METHYL-3,4-METHYLENEDIOXY CHALCONE
4-Butoxy-3',4',5'-trimethoxy-trans-chalcone
3-Dimethylamino-3',4',5'-trimethoxy-trans-chalcone
3,4'-Dinitro-trans-chalcone
4-Diethylamino-α-methyl-2',3',4'-trimethoxy-trans-chalcone
4-Nitro-3',4',5'-trimethoxy-trans-chalcone