클로펙사미드

클로펙사미드
클로펙사미드 구조식 이미지
카스 번호:
1223-36-5
한글명:
클로펙사미드
동의어(한글):
클로펙사미드
상품명:
clofexamide
동의어(영문):
ANP246;NP-246;IEM-455;ANP 246;ANP-246;clofexamide;Chlofexamide;Amichlophene;2-(4-Chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide;Acetamide, 2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]-
CBNumber:
CB0884312
분자식:
C14H21ClN2O2
포뮬러 무게:
284.78
MOL 파일:
1223-36-5.mol

클로펙사미드 속성

녹는점
45 °C
끓는 점
124.5°C (rough estimate)
밀도
1.1742 (rough estimate)
굴절률
1.5200 (estimate)
산도 계수 (pKa)
14.19±0.46(Predicted)

안전

독성 LD50 oral in rat: 1040mg/kg

클로펙사미드 C화학적 특성, 용도, 생산

Originator

Clofexamide ,CNRS

Manufacturing Process

In 1 L of water there is dissolved 116.0 g (1 mole) of N,Ndiethylethylenediamine and, under vigorous stirring at a temperature maintained below 50°C, there is added 205.0 g (1 mole) of the chloride of pchlorphenoxyacetic acid. The solution becomes rapidly homogeneous; the formation of the basic amide hydrochloride is rapidly completed by further stirring the reaction mixture for 2 h at about 20°C. Then an excess of soda lye is added and the basic amide formed is extracted by ether. The ethereal solution is dried on anhydrous sodium sulfate and ether is distilled after that the residue is dried. So 2-(p-chlorophenoxy)-N-(2-(diethylamino)ethyl) acetamide is obtained.

Therapeutic Function

Antidepressant, Analgesic, Antiinflammatory, Local anesthetic

클로펙사미드 준비 용품 및 원자재

원자재

준비 용품


클로펙사미드 공급 업체

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