(S)-2-클로로-5,6,7,8,9,10-헥사히드로시클로헵타[b]인돌-6-카르복사미드
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(S)-2-클로로-5,6,7,8,9,10-헥사히드로시클로헵타[b]인돌-6-카르복사미드 속성
- 저장 조건
- 2-8°C
- 용해도
- DMSO: >10mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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신호 어: | Danger | |||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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(S)-2-클로로-5,6,7,8,9,10-헥사히드로시클로헵타[b]인돌-6-카르복사미드 C화학적 특성, 용도, 생산
일반 설명
A cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322). Shown to be orally bioavailable with a serum half-life of 94 minutes in mice in vivo.Biochem/physiol Actions
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.(S)-2-클로로-5,6,7,8,9,10-헥사히드로시클로헵타[b]인돌-6-카르복사미드 준비 용품 및 원자재
원자재
준비 용품
(S)-2-클로로-5,6,7,8,9,10-헥사히드로시클로헵타[b]인돌-6-카르복사미드 공급 업체
글로벌( 7)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Syntechem Co.,Ltd | |
info@syntechem.com | China | 12990 | 57 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 |
shenlinxing@macklin.cn | China | 29802 | 58 |
TargetMol Chemicals Inc. | 15002134094 |
marketing@targetmol.cn | China | 19696 | 58 |