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ChemicalBook >> CAS DataBase List >>(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Structure
(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide structure
CAS No.
848193-72-6
Chemical Name:
(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide
Synonyms
CHIC-35;Compound (S)-35;SIRT1 Inhibitor IV, (S)-35;SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem;(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide;(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide;Cyclohept[b]indole-6-carboxamide, 2-chloro-5,6,7,8,9,10-hexahydro-, (6S)-
CBNumber:
CB12676079
Molecular Formula:
C14H15ClN2O
Molecular Weight:
262.73
MDL Number:
MFCD11045286
MOL File:
848193-72-6.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:18
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(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Properties

storage temp. 2-8°C
solubility DMSO: >10mg/mL
form solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P261-P301+P310-P305+P351+P338
Hazard Codes  Xn
Risk Statements  36/37/38
Safety Statements  26
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C8742 CHIC-35 ≥97% (chiral, HPLC) 848193-72-6 1mg $188 2024-03-01 Buy
Sigma-Aldrich 566325 SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem 848193-72-6 500μg $216 2024-03-01 Buy
Sigma-Aldrich C8742 CHIC-35 ≥97% (chiral, HPLC) 848193-72-6 5mg $582 2024-03-01 Buy
American Custom Chemicals Corporation INB0004657 (6S)-2-CHLORO-5,6,7,8,9,10-HEXAHYDRO-CYCLOHEPT[B]INDOLE-6-CARBOXAMIDE 95.00% 848193-72-6 5MG $498.64 2021-12-16 Buy
Product number Packaging Price Buy
C8742 1mg $188 Buy
566325 500μg $216 Buy
C8742 5mg $582 Buy
INB0004657 5MG $498.64 Buy

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Chemical Properties,Uses,Production

Definition

ChEBI: CHIC-35 is an organic heterotricyclic compound resulting from the formal fusion of the 2-3 bond of 5-chloroindole with the 2-3 bond of cycloheptanecarboxamide (the S enantiomer). It is a potent, cell-permeable, metabolically stable and selective inhibitor of the deacetylase SIRT1. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor. It is an aromatic compound, an organic heterotricyclic compound, an organochlorine compound and a primary carboxamide.

General Description

A cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322). Shown to be orally bioavailable with a serum half-life of 94 minutes in mice in vivo.

Biochem/physiol Actions

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Syntechem Co.,Ltd info@syntechem.com China 12990 57
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939 shenlinxing@macklin.cn China 29803 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Syntechem Co.,Ltd 57
Sigma-Aldrich 80
TargetMol Chemicals Inc. 58
Shanghai Maclean Biochemical Technology Co., LTD 58
(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide CHIC-35 Compound (S)-35 SIRT1 Inhibitor IV, (S)-35 (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem Cyclohept[b]indole-6-carboxamide, 2-chloro-5,6,7,8,9,10-hexahydro-, (6S)- 848193-72-6