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ChemicalBook >> CAS DataBase List >> (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide price.
  • $188 - $582
  • Product name: (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide
  • CAS: 848193-72-6
  • MF: C14H15ClN2O
  • MW: 262.73
  • EINECS:
  • MDL Number:MFCD11045286
  • Synonyms:(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide;CHIC-35;Compound (S)-35;SIRT1 Inhibitor IV, (S)-35;(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide;SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem;Cyclohept[b]indole-6-carboxamide, 2-chloro-5,6,7,8,9,10-hexahydro-, (6S)-
Price4 Properties Safety Information Description
4 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • Sigma-Aldrich
Package
  • 500μg
  • 1mg
  • 5MG
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004657
  • Product description(6S)-2-CHLORO-5,6,7,8,9,10-HEXAHYDRO-CYCLOHEPT[B]INDOLE-6-CARBOXAMIDE 95.00%
  • Packaging5MG
  • Price$498.64
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberC8742
  • Product descriptionCHIC-35 ≥97% (chiral, HPLC)
  • Packaging1mg
  • Price$188
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number566325
  • Product descriptionSIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem
  • Packaging500μg
  • Price$216
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberC8742
  • Product descriptionCHIC-35 ≥97% (chiral, HPLC)
  • Packaging5mg
  • Price$582
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation INB0004657 (6S)-2-CHLORO-5,6,7,8,9,10-HEXAHYDRO-CYCLOHEPT[B]INDOLE-6-CARBOXAMIDE 95.00% 5MG $498.64 2021-12-16 Buy
Sigma-Aldrich C8742 CHIC-35 ≥97% (chiral, HPLC) 1mg $188 2024-03-01 Buy
Sigma-Aldrich 566325 SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem 500μg $216 2024-03-01 Buy
Sigma-Aldrich C8742 CHIC-35 ≥97% (chiral, HPLC) 5mg $582 2024-03-01 Buy

Properties

storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :solid

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SIRT 1 inhibitor IV, (S)-35 is a highly potent inhibitor of SIRT1 (IC50 = 38 nM). It is an entomerically pure compound that can permeate the cell and is metabolically stable. The inhibitor is similar in structure, potency (IC50 = 63 nM), and selectivity to SIRT1 inhibitor III. Sirt4-7 and class I/II HDAC are not inhibited by SIRT1 inhibitor (concentrations up to 100μM). Data shows that inhibition of SIRT1 by SIRT1 Inhibitor IV, (S)-35 enhances acetylation of p53 in response to DNA damaging agents.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Aladdin Scientific Syntechem Co.,Ltd Sigma-Aldrich TargetMol Chemicals Inc. Shanghai Maclean Biochemical Technology Co., LTD