아세토헥사마이드
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아세토헥사마이드 속성
- 녹는점
- 188-190° (GB 912789); mp 175-177° (Marshall)
- 밀도
- 1.2528 (rough estimate)
- 굴절률
- 1.6930 (estimate)
- 저장 조건
- Refrigerator
- 용해도
- DMSO: ~45 mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.32±0.10(Predicted)
- 색상
- 하얀색
- 수용성
- 0.25g/L(25℃)
- CAS 데이터베이스
- 968-81-0
안전
안전지침서 | 36 | ||
---|---|---|---|
WGK 독일 | 2 | ||
RTECS 번호 | YR7350000 | ||
유해 물질 데이터 | 968-81-0(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: > 2gm/kg |
아세토헥사마이드 C화학적 특성, 용도, 생산
용도
Acetohexamide is a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diabetes metilus type 2.정의
ChEBI: An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a p-acetylphenylsulfonyl group, while a hydrogen attached to the other nitrogen is replaced by a cyclohexyl group.일반 설명
Acetohexamide is 4-acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide; or 1-[(p-acetylphenyl)sulfonyl]-3-cyclohexylurea; or 1-(p-acetylbenzenesulfonyl)-3-cyclohexylurea(generic). Acetohexamide incorporates the nearly optimal(for potency) cyclohexyl moiety in the “right-hand” sideof its molecular structure, but a p-acetyl substituent on the“left-side” benzene ring that decreases lipophilicity and israpidly biotransformed by reduction to an active metabolitethat is cleared relatively rapidly (see preceding discussion) independentlyof any P450s.공기와 물의 반응
Water insoluble.반응 프로필
An amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).화재위험
Flash point data for ACETOHEXAMIDE are not available; however, ACETOHEXAMIDE is probably combustible.Clinical Use
Acetohexamide is metabolized in the liver to a reducedform, the α -hydroxyethyl derivative. This metabolite, themain one in humans, possesses hypoglycemic activity.Acetohexamide is intermediate between tolbutamide andchlorpropamide in potency and duration of effect on bloodsugar levels.Safety Profile
Human reproductive effects by an unspecified route: stillbirth. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of SO, and NOx,.아세토헥사마이드 준비 용품 및 원자재
원자재
준비 용품
아세토헥사마이드 공급 업체
글로벌( 85)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29825 | 58 |
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 |
18522618860@163.com | China | 694 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 |
contact@labnetwork.com | China | 19994 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 8722 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
아세토헥사마이드 관련 검색:
B-I-K 아세토헥사마이드
Amlodipine
carbutamide
TOLAZAMIDE
Glibenclamide
glycyclamide
N-CYCLOHEXYLFORMAMIDE
4-Methylphenylsulfonylurea
Cyclohexylurea
4-Ethylbenzenesulfonamide
4-Acetylbenzenesulphonamide
ANTI-ACETOHEXAMIDE
acetohexamide reductase
Acetohexamide-(o-carboxymethyl) oxime-KLH, Sheep anti-, Polarisation fluoroimmunoassay
N-(aminocarbonyl)benzenesulphonamide
4-METHYLSULFAMYL-ACETOPHENONE