Buspirone
|
|
Buspirone 속성
- 녹는점
- 105-107 °C(Solv: ethyl acetate (141-78-6))
- 끓는 점
- 511.93°C (rough estimate)
- 밀도
- 1.1527 (rough estimate)
- 굴절률
- 1.7600 (estimate)
- 저장 조건
- Sealed in dry,2-8°C
- 산도 계수 (pKa)
- pKa 7.60±0.01(H2O t=25.0 I=0.1(NaCl)) (Uncertain)
- 물리적 상태
- Solid
- 색상
- White to off-white
- BCS Class
- 1
- CAS 데이터베이스
- 36505-84-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
그림문자(GHS): |
![]() |
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
신호 어: | Danger | ||||||||||||||||
유해·위험 문구: |
|
||||||||||||||||
예방조치문구: |
|
Buspirone C화학적 특성, 용도, 생산
용도
Buspirone is an extremely specific drug that could possibly represent a new chemical class of anxiolytics—azaspirones. As an anxiolytic, its activity is equal to that of benzodiazepines; however, it is devoid of anticonvulsant and muscle relaxant properties, which are characteristic of benzodiazepines.정의
ChEBI: An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N4 position.Biological Functions
Buspirone (BuSpar) is the first example of a class of anxiolytic agents that can relieve some symptoms of anxiety in doses that do not cause sedation. Buspirone is structurally unrelated to existing psychotropic drugs.일반 설명
The initial compound in this series, buspirone (BuSpar), hasanxiolytic and antidepressant activities and is a partial5-HT1A agonist. Its anxiolytic activity is reportedly causedby its ability to diminish 5-HT release (via 5-HT1A agonism).High short-term synaptic levels of 5-HT are characteristic ofanxiety. Also, because it is a partial agonist, it can stimulatepostsynaptic receptors when 5-HT levels are low in thesynapse, as is the case in depression. Several other spironesare in development as anxiolytics and antidepressants.Mechanism of action
Although buspirone has been shown to interact with a number of neurotransmitter systems in the brain, it appears that its clinically relevant effects are mediated through interactions at the serotonin (5-hydroxytryptamine, 5-HT) 5-HT1A receptor, where it acts as a partial agonist.Pharmacology
Buspirone is as effective as the benzodiazepines in the treatment of general anxiety. However, the full anxiolytic effect of buspirone takes several weeks to develop, whereas the anxiolytic effect of the benzodiazepines is maximal after a few days of therapy. In therapeutic doses, buspirone has little or no sedative effect and lacks the muscle relaxant and anticonvulsant properties of the benzodiazepines. In addition, buspirone does not potentiate the central nervous system depression caused by sedative–hypnotic drugs or by alcohol, and it does not prevent the symptoms associated with benzodiazepine withdrawal.Clinical Use
Buspirone is effective in general anxiety and in anxiety with depression.부작용
Like the benzodiazepines, buspirone appears to be safe even when given in very high doses. The most common side effects are dizziness, light-headedness, and headache. Abuse, dependence, and withdrawal have not been reported, and buspirone administration does not produce any cross-tolerance to the benzodiazepines. Buspirone has been reported to increase blood pressure in patients taking monoamine oxidase inhibitors, and it may increase plasma levels of haloperidol if coadministered with that agent.신진 대사
Buspirone is well absorbed from the gastrointestinal tract, and peak blood levels are achieved in 1 to 1.5 hours; the drug is more than 95% bound to plasma proteins. Buspirone is extensively metabolized, with less than 1% of the parent drug excreted into the urine unchanged. At least one of the metabolic products of buspirone is biologically active. The parent drug has an elimination half-life of 4 to 6 hours.Buspirone 준비 용품 및 원자재
원자재
Concentrated hydrochloric acid
2-(1-피페라지닐)피리미딘
글루타이미드
트리에틸아민
2-Aminopyrimidine
클로로포름
피페라진
아질산 나트륨
2-Chloropyrimidine
디클로로메탄
글루타릭 안하이드라이드
2-시아노아세트아미드
글루타르산
사이클로펜타논
이소프로필알코올
시안초산메틸
준비 용품
Buspirone 공급 업체
글로벌( 115)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12449 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 265 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21668 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29892 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 |
mcbio_sales@163.com | China | 2255 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 |
Ethan@dornechem.com | China | 3145 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24330 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9602 | 58 |
Buspirone 관련 검색:
아세트산부틸 N-데칸 아크릴산부탄 브푸로페진 tert-부틸알코올 피페라진 에틸렌글리콜모노부틸에테르 1-아미노에틸피페라진 N-메틸피페라진 호모피페라진 버스피론 수화염화물
2-Ethylhexyl ferulate
Piperacillin
Bromophenol Red
BUSPIRONE (D8),BUSPIRONE-D8 HCL (BUTYL-D8),Buspirone-d8 Hydrochloride,Buspirone-d8 HCl
6-HYDROXY BUSPIRONE
6-Hydroxy Buspirone-d8
BUSPIRONE FOR SYSTEM SUITABILITY