N-말레오일-β-알라닌
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N-말레오일-β-알라닌 속성
- 녹는점
- 103-106 °C (lit.)
- 끓는 점
- 382.5±25.0 °C(Predicted)
- 밀도
- 1.473±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 4.18±0.10(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 하얀색
- 수용성
- 메탄올, 디메틸 포름아미드, 알코올 및 디메틸 설폭사이드에 용해됩니다. 물에 약간 용해됩니다.
- 감도
- Moisture Sensitive
- BRN
- 1528952
- InChIKey
- IUTPJBLLJJNPAJ-UHFFFAOYSA-N
- CAS 데이터베이스
- 7423-55-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
N-말레오일-β-알라닌 C화학적 특성, 용도, 생산
화학적 성질
White to Pale Yellow Solid용도
3-Maleimidopropionic acid is a sulfhydryl reactive heterobifunctional crosslinking reagent.주요 응용
3-Maleimidopropionic acid (3MP) is a molecule that can be used for the treatment of cancer. 3MP has been shown to inhibit the growth of tumor cells and induce apoptosis. It also inhibits the production of reactive oxygen species, which are produced by cancer cells as a result of chemotherapy. 3MP has potent inhibitory activity against bacterial organisms such as methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens and antiviral properties against HIV infection. This molecule can also be used in conjunction with monoclonal antibodies or other immunotherapy techniques to improve their efficacy.일반 설명
N-Maleoyl-β-alanine (3-maleimidopropanoic acid) is an aliphatic N-substituted maleimide. It is one of the component of the stabilizing solution for EC145 (a folate-targeted vinca alkaloid conjugate) used in rodent pharmacokinetic studies.Synthesis
An acetic acid solution of maleic anhydride (5.00 g in 50 mL) was added dropwise to an acetic acid solution of β-alanine (4.54 g in 50 mL). The mixture was stirred at room temperature. After 3 h, AcOH (70 mL ) was added and the temperature was raised to 115 °C under stirred overnight. After 1 hour, an orange oil was obtained. The solvent excess was removed under reduced pressure and the product was washed with toluene (3 × 30 mL). The product was then purified by flash chromatography using a silica column (DCM/ethylacetate 9:1) to obtain the white solid 3-Maleimidopropionic acid.![3-Maleimidopropionic acid 3-Maleimidopropionic acid](/NewsImg/2023-10-20/6383339205802274188401769.jpg)
N-말레오일-β-알라닌 준비 용품 및 원자재
원자재
베타-알라닌
말레산 무수물
톨루엔
2,3-DICHLORO-5,8-DIHYDROXY-1,4-나프토퀴논
펜탄디온(2,3-)
아세트산(빙초산)
CIS-5-AZA-4-OXO-OCT-2-EN-DIOIC ACID
준비 용품
N-말레오일-β-알라닌 공급 업체
글로벌( 314)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 |
sales@ansciepchem.com | CHINA | 4242 | 58 |
Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 19343 | 58 |
Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 |
export@pu-kang.com | CHINA | 210 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
N-말레오일-β-알라닌 관련 검색:
숙신산이미드 1,1'(1,3-페닐렌)비스-1H-피롤-2,5-디온 글리신 시트르산 엽산 아세트산 4,4'-디페닐메탄 비스-말린이미드 프탈이미드 말레이미디 4-말레이미도부티르 산 다이알리포르(디알리포르) N-말레오일-β-알라닌
Ascoric Acid
BETA-MALEIMIDOPROPIONIC ACID,N-BETA-MALEIMIDOPROPIONIC ACID
N-Succinimidyl 3-maleimidopropionate
N-Succinimidyl 6-maleimidohexanoate
MALEIMIDOPROPIONIC ACID HYDRAZIDE HYDROCHLORIDE,MALEIMIDOPROPIONIC ACID HYDRAZIDE HCL
MALEIMIDOPROPIONIC ACID N-HYDROXYSULFOSUCCINIMIDE ESTER,MALEIMIDOPROPIONIC ACID N-HYDROXYSULPHOSUCCINIMIDE ESTER