테트라카인하이드로클로라이드
|
|
테트라카인하이드로클로라이드 속성
- 녹는점
- 149°C
- 밀도
- 1.1279 (rough estimate)
- 굴절률
- 1.5200 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 알코올: 용매 40부에 용해됨
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 8.39(at 25℃)
- 색상
- 흰색에서 거의 흰색
- 수용성
- 50mg/ml의 물에 용해됨
- Merck
- 14,9188
- InChI
- InChI=1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H
- InChIKey
- PPWHTZKZQNXVAE-UHFFFAOYSA-N
- SMILES
- C1(C=CC(NCCCC)=CC=1)C(=O)OCCN(C)C.Cl
- LogP
- 3.649 (est)
- CAS 데이터베이스
- 136-47-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T | ||
---|---|---|---|
위험 카페고리 넘버 | 25-36-43-42/43 | ||
안전지침서 | 26-36/37-45-36/37/39-22-53 | ||
유엔번호(UN No.) | 2811 | ||
WGK 독일 | 3 | ||
RTECS 번호 | DG4900000 | ||
위험 등급 | 6.1 | ||
포장분류 | III | ||
HS 번호 | 29224999 | ||
독성 | LD50 i.p. in mice: 70 mg/kg (Dawes); also reported as LD50 in female mice (mg/kg): 13 i.v.; 35 s.c. (Bopp) |
테트라카인하이드로클로라이드 C화학적 특성, 용도, 생산
화학적 성질
Tetracaine hydrochloride is a white, crystalline powder, odourless; hygroscopic; it has a slightly bitter taste and causes local numbness after being placed on the tongue. Soluble in water, soluble in ethanol (~750 g/l), practically insoluble in ether. even in the absence of light, it is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures.용도
Tetracaine hydrochloride is a local anesthetic used topically in opthalmology.It is a highly effective local anesthetic that reversibly blocks nerve function. It is clinically used for infiltration anesthesia, nerve block anesthesia, epidural anesthesia, etc. Compared with procaine, its local anesthesia effect is remarkable. Tetracaine hydrochloride has been widely used in clinical practice.제조 방법
Synthesis of tetracaine hydrochloride using 4-Methyl-2-pentanone as starting material: To the reaction kettle, first add 320.0kg of methyl isobutyl ketone, then add 40.0kg (207mol) of 4-Butylaminobenzoic acid and 56.8kg of anhydrous potassium carbonate in turn, heat the oil bath to 116°C for reflux reaction for 4h, stop heating, and react for a while. Cool for 0.5h, then add 38.3kg (266mol) of 2-Dimethylaminoethyl Chloride Hydrochloride, continue to heat to 116°C for reflux reaction for 4h, and cool to below 30°C after the reaction is complete, then add deionized water 127.0 kg stirred for 30min, left standing for 1h, separated the organic layer, dried and concentrated to obtain an oily substance, then added 169.0kg of acetone and stirred, adjusted the pH value with concentrated hydrochloric acid to 3-4, and precipitated a large number of crystals, which continued to crystallize for 12h after freezing. , centrifugal filtration and drying to obtain 53.0kg of white solid which is tetracaine hydrochloride, the yield is 85.07%, and the HPLC purity is 99.34%.주요 응용
Tetracaine hydrochloride is also known as ropivacaine hydrochloride, pantocaine, pantocaine and four ropivacaine hydrochloride. It is easily soluble in water and ethanol, but insoluble in ether, benzene. Tetracaine hydrochloride is a local anesthetic with long-acting ester. In addition, procaine is widely used in clinical, but because of its poor permeability and poor narcotic performance, a small tetracaine was found in 1930 found.Tetracaine hydrochloride can be used for topical anesthesia, and 0.05%-0.1% tetracaine hydrochloride can provide long-term and good effect of surface anesthesia. Meanwhile, tetracaine hydrochloride is still widely used in ophthalmic surface anesthesia, which has a long time for surface anesthesia and sensory resistance.
정의
ChEBI: Tetracaine hydrochloride is a benzoate ester. It is a potent local anesthetic of the ester type used for surface and spinal anesthesia.일반 설명
Tetracaine hydrochloride is a local anesthetic drug and an ester derivative of p-amino benzoic acid. It acts by interfering with the entry of sodium ions into nerve cells and is one of the commonly used topical anesthetics.색상 색인 번호
Amethocaine is a local anesthetic used in dental surgery. It was reported as an agent of contact dermatitis in dentists or dental nurses and in ophthalmologists부작용
Tetracaine hydrochloride is in the ester-type local anesthetic family of medications. It works by blocking the sending of nerve impulses. common side effects include Transient stinging, burning, and conjunctival redness, eye irritation, eye pain, ocular discomfort. Allergic reactions may uncommonly occur. Long term use is generally not recommended as it may slow healing of the eye. It is unclear if use during pregnancy is safe for the baby.?? ??
Tetracaine hydrochloride (TTC) is a long-lasting local anesthetic commonly used for topical anesthesia, which is water-soluble, has strong penetrability and a good anesthetic effect. However, TTC has a higher cytotoxicity compared with other local anesthetics due to its high permeability. Previous studies have reported that TTC exerts a cytotoxic effect on certain cell types, such as human corneal stromal cells and human corneal epithelial cells, inducing apoptosis and necrosis. Research jave found that large doses of intrathecal TTC increase the concentration of glutamate in cerebrospinal fluid, thereby causing neuronal injury in rabbits. In addition, AMPA receptor activation was revealed to be involved in TTC-induced neurotoxicity in the spinal cord. TTC-induced apoptosis may be triggered through Fas death receptors and mediated by Bcl-2 family proteins, in a mitochondria-dependent pathway. TTC-induced human corneal epithelial (HCEP) cell apoptosis via a death receptor-mediated mitochondrion-dependent pathway. Low concentrations of TTC induced the apoptosis of human T-lymphoma cells, whereas a higher concentration of TTC induced necrosis[1].테트라카인하이드로클로라이드 준비 용품 및 원자재
원자재
준비 용품
테트라카인하이드로클로라이드 공급 업체
글로벌( 613)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 |
sales@chembj.net | China | 289 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12450 | 58 |
Shandong Hanjiang Chemical Co., Ltd | +86-0533-2066820 +8618369939125 |
hanson@sdhanjiang.com | China | 975 | 58 |
Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 |
3684455296@qq.com | China | 9311 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 |
sales8@hbganmiao.com | China | 300 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3320 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 436 | 58 |
Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 |
sales1@hbganmiao.com | China | 253 | 58 |
shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 |
sales@sdperfect.com | China | 294 | 58 |
테트라카인하이드로클로라이드 관련 검색:
에틸파라벤 4-아미노벤조산 다이메틸아민 수화염화물 3-(디메틸아미노)프로필아민 글리신 에틸에스터 염화수소 에틸알코올 초산에틸 D-글루코사민 안트라닐산 벤조산-2-디메틸아미노에틸에스테르
4-(BUTYLAMINO)BENZOIC ACID
4-AMINOAZOBENZENE HYDROCHLORIDE
Topotecan hydrochloride
Tetracaine
Tris(trimethylsilyl)phosphate
Proparacaine hydrochloride
4-(Butylamino)-benzoic acid, methyl ester
Tetracaine for system suitability