LIPID A, DIPHOSPHORYL FROM ESCHERICHIA COLI F-583 (RD MUTANT)
동의어(영문):
lipid A, diphosphoryl;LIPID A, DIPHOSPHORYL FROM SALMONELLA*MI NNESOTA RE-;LIPID A, DIPHOSPHORYL FROM ESCHERICHIA COLI F-583 (RD MUTANT);LIPID A, DIPHOSPHORYL FROM SALMONELLA MINNESOTA RE-595 (R MUTANTS);lipid a, diphosphoryl from salmonella enterica serotype minnesota re 595 (re mutant);2-deoxy-6-O-<2-deoxy-2-<(R)-3-dodecanoyloxytetradecanoylamino>-3-O-<(R)-3-tetradecanoyloxytetradecanoyl>-β-D-glucopyranosyl>-3-O-<(R)-3-hydroxytetradecanoyl>-2-<(R)-3-hydroxytetradecanoylamino>-α-D-glucopyranose 1,4'-bis(phosphate);α-D-Glucopyranose, 2-deoxy-6-O-[2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-β-D-glucopyranosyl]-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-, 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate];α-D-Glucopyranose, 2-deoxy-6-O-[2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-β-D-glucopyranosyl]-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-, 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate]
Lipid A, diphosphoryl from?Escherichia coli?F583 (Rd mutant) has been used:
to study the effect of various lipid A molecules on lung pericyte proliferation in vitro
to test on THP-1 and J774A.1 cells for neopterin and nitrite formation respectively
as lipopolysaccharides (LPS) derivatives in binding experiments
to stimulate the spleen cells and as a mitogen stimulation for toll like receptor 4 (TLR4)
일반 설명
Lipid A is the fundamental structure of lipopolysaccharides (LPS), present in bacteria.
Biochem/physiol Actions
Lipid A is mainly essential for the robust immunostimulatory activities of lipopolysaccharides (LPS) in human. Lipid A is the hydrophobic domain of LPS helps in anchoring LPS to the plasma membrane of bacteria. It is immunologically active and an important constituent of LPS recognised by immune system.
