AICAR
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AICAR 속성
- 녹는점
- 214-215 °C
- 끓는 점
- 726.3±60.0 °C(Predicted)
- 밀도
- 2.06±0.1 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- H2O: >10 mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 13.27±0.70(Predicted)
- 색상
- 갈색을 띤 노란색
- 수용성
- 2mg/ml의 DMSO에 용해됩니다. 1mg/ml 미만으로 물이나 에탄올에 용해됩니다.
- 최대 파장(λmax)
- 265nm(NaOH)(lit.)
- Merck
- 14,16
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 증류수에 용해된 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- InChIKey
- RTRQQBHATOEIAF-UUOKFMHZSA-N
- CAS 데이터베이스
- 2627-69-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,T | ||
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위험 카페고리 넘버 | 36/37/38-61 | ||
안전지침서 | 26-36-45-53 | ||
WGK 독일 | 3 | ||
TSCA | Yes | ||
HS 번호 | 29349990 |
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Danger | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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AICAR C화학적 특성, 용도, 생산
화학적 성질
Solid용도
AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.정의
ChEBI: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.일반 설명
Adenosine monophosphate?protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide?ribonucleotide?(AICAR)?modulates cellular energy. It regulates lipid and glucose metabolism, pro-inflammatory responses,?cytokine production,?cell proliferation and apoptosis. AICAR improves ischemia or reperfusion injury and kidney fibrosis in rats. It provides protection against acute tubular necrosis.생물학적 활성
Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.Clinical claims and research
AICAR has proved in vivo anti-tumor effects in xenograft models. It is currently under clinical trial phase I/II to treat patients with chronic lymphocytic leukemia and has shown good safety and tolerability properties, although some side effects have been reported.AICAR 준비 용품 및 원자재
원자재
준비 용품
AICAR 공급 업체
글로벌( 345)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 |
ably@aljbio.com | China | 145 | 58 |
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. | +8618068519287 |
sales@xuanmingchem.com | China | 882 | 58 |
Zhuzhou New Peptides Tech Co.,Ltd. | +86-18073326374 +86-18073326374 |
sales@goodpeptides.com | China | 145 | 58 |
Hong Kong Excellence Biotechnology Co., Ltd. | |
ada@sh-teruiop.com | China | 882 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 436 | 58 |
Wuhan Ruichi Technology Co., Ltd | +8613545065237 |
admin@whrchem.com | China | 161 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 |
admin@oudaxin.com | China | 114 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12450 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Wuhan Han Sheng New Material Technology Co.,Ltd | +8617798174412 |
admin01@hsnm.com.cn | China | 2118 | 58 |
AICAR 관련 검색:
구아노신 5′-이노신산이나트륨
AICAR (phosphate)
Inosine Impurity 1
L-Inosine
Inosine
2-CHLOROINOSINE
IDP
XANTHOSINE
2',3',5'-TRI-O-ACETYLINOSINE
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
2',3'-O-Isopropylideneinosine
XANTHOSINE 5'-MONOPHOSPHATE DISODIUM SALT
3'-GMP DISODIUM SALT
2'-Deoxyguanosine-5'-diphosphate trisodium salt
Succino-AICAR
5-Amino-4-imidazolecarboxamide
CYTIDYLYL-(3'->5')-GUANOSINE