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부클록신산

부클록신산 구조식 이미지

카스 번호:: 32808-51-8

한글명:: 부클록신산

동의어(한글):: 부클록신산

상품명:: bucloxic acid

동의어(영문):: Esfar;804CB;Bucloxic;bucloxic acid;Acide bucloxique;32808-53-0 (Calcium salt);Acide bucloxique [inn-french];32808-52-9 (Hydrochloride-salt);3-Chloro-4-cyclohexyl-γ-oxobenzenebutyric acid;3-(3-chloro-4-cyclohexylbenzoyl)propionic acid

CBNumber:: CB1924022

분자식:: C16H19ClO3

포뮬러 무게:: 294.776

MOL 파일:: 32808-51-8.mol

속성

안전

용도

공급 업체 8

부클록신산 속성

녹는점: 163°

끓는 점: 408.08°C (rough estimate)

밀도: 1.1280 (rough estimate)

굴절률: 1.4585 (estimate)

저장 조건: Store at -20°C

용해도: DMSO에 용해됨

산도 계수 (pKa): 4.43±0.17(Predicted)

안전

독성	LD50 in mice, rats (mg/kg): 900, 120 orally; 1100, 210 i.p (Krausz, p. 1360)

부클록신산 C화학적 특성, 용도, 생산

Originator

Esfar,Clin Midy,France,1974

Manufacturing Process

Phenylcyclohexane and succinic acid (Bernstein Acid) anhydride are reacted in the presence of AlCl3to give 4-(4'-cyclohexylphenyl)-4-keto-n-butyric acid.
177 grams of anhydrous aluminum chloride are introduced into a 3-necked 1 liter flask. A hot solution of 144 grams of 4-(4'-cyclohexylphenyl)-4-keto-nbutyric acid in 330 ml of methylene chloride is added slowly from a dropping funnel. Slight reflux is observed during this addition. 33.2ml of liquefied chlorine are then introduced slowly, drop by drop. This addition requires 5 hours. The solution is then poured on to 1 kg of ice containing 100 ml of concentrated hydrochloric acid. The aqueous phase is extracted twice, each time with 200 ml of methylene chloride, the organic phase is washed with water to pH 6.5 and dried and the organic solvent then evaporated. The desired acid is recrystallized from 500 ml of toluene. The yield is 64%. MP: 159°C.

Therapeutic Function

Antiinflammatory

부클록신산 준비 용품 및 원자재

원자재

2-Oxobutyric acid 페닐사이클로헥세인 숙신산무수물 염소(기체)

준비 용품

부클록신산 공급 업체

글로벌( 8)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shenzhen Regent Biochemical Technology Co., Ltd.	0755-0755-85201366 18938635012	sales@regentsciences.com	China	9302	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223;	psaitong@jm-bio.com	China	29778	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Shaanxi Dideu Newmaterial Co., Ltd.	029-63373950 15353716720	1052@dideu.com	China	10011	58
Suzhou Haiben Pharmaceutical Co., Ltd	14760821013 14760821013	1816280386@qq.com	China	5662	58

부클록신산 관련 검색:

프로피온산칼슘 bucloxic acid 4'-CYCLOHEXYLACETOPHENONE 4-(3-chlorophenyl)butanoicacid CALCIUM BUTYRATE calcium 3-chloro-4-cyclohexyl-gamma-oxobenzenebutyrate 3-(3-Chloro-4-methylbenzoyl)propionic acid 3-CHLORO-4-CYCLOHEXYL-BENZALDEHYDE 4-OXO-4-(4-PENTYLPHENYL)BUTANOIC ACID 1-(4-SEC-BUTYLPHENYL)PROPAN-1-ONE 1-(4-PENTYLPHENYL)PROPAN-1-ONE 4-(4-ISOPROPYL-PHENYL)-4-OXO-BUTYRIC ACID 4-(3-CHLOROPHENYL)-4-OXOBUTYRIC ACID 4-OXO-4-(4-PROPYLPHENYL)BUTANOIC ACID CHEMBRDG-BB 4002815 p-cyclohexylbenzaldehyde 4-cyclohexyl-gamma-oxobenzenebutyric acid 4-(4-N-BUTYLPHENYL)-4-OXOBUTYRIC ACID